RecruitingPhase 3

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

NCT06937229

What is this trial?

Generating plain-language summary...

Am I eligible?

Generating eligibility summary...

What's involved?

Summarizing study design...

Where and how to apply

Primary location

Local Institution - 2609

Chandler, Arizona, United States

+240 additional locations

Contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com

855-907-3286 Clinical.Trials@bms.com

View on ClinicalTrials.gov

Save this trial

Quick facts

Start date: 2025-12-02
Enrollment: 600 participants
Sponsor: Bristol-Myers Squibb
Purpose: treatment

Locations (241)

Local Institution - 2609Chandler, Arizona, United States
Imaging EndpointsScottsdale, Arizona, United States
Local Institution - 1657Anaheim, California, United States
Local Institution - 2620Canoga Park, California, United States
Local Institution - 1637La Jolla, California, United States
Local Institution - 2625Long Beach, California, United States
Local Institution - 2607Long Beach, California, United States
Local Institution - 2642Long Beach, California, United States
Local Institution - 2613Pasadena, California, United States
Local Institution - 1662Pomona, California, United States
Local Institution - 1639Torrance, California, United States
Local Institution - 1651Walnut Creek, California, United States
Local Institution - 2602Bonita Springs, Florida, United States
Local Institution - 2626Hialeah, Florida, United States
Local Institution - 1602Miami, Florida, United States
Local Institution - 1618Miami, Florida, United States
Local Institution - 1609Miami, Florida, United States
Nuovida Research CenterMiami, Florida, United States
Local Institution - 1635Orlando, Florida, United States
Progressive Medical ResearchPort Orange, Florida, United States
IPTB Clinical ResearchTampa, Florida, United States
Local Institution - 1636Gaithersburg, Maryland, United States
Boston Center for MemoryNewton, Massachusetts, United States
Local Institution - 2615Worcester, Massachusetts, United States
Local Institution - 2618Ann Arbor, Michigan, United States
Local Institution - 1620Troy, Michigan, United States
Local Institution - 2256Saint Paul, Minnesota, United States
Local Institution - 2629Hattiesburg, Mississippi, United States
Local Institution - 2628Las Vegas, Nevada, United States
Local Institution - 1649Las Vegas, Nevada, United States
Local Institution - 1647West Long Branch, New Jersey, United States
Local Institution - 1656New Windsor, New York, United States
Local Institution - 2619Staten Island, New York, United States
Local Institution - 1658Woodmere, New York, United States
West Clinical ResearchMorehead City, North Carolina, United States
Local Institution - 2617Blue Ash, Ohio, United States
Local Institution - 1640Tulsa, Oklahoma, United States
Local Institution - 1653Columbia, South Carolina, United States
Epic Medical Research, LLC - CarroltonCarrollton, Texas, United States
Local Institution - 2605Cypress, Texas, United States
Local Institution - 1643El Paso, Texas, United States
Local Institution - 2622Mesquite, Texas, United States
Local Institution - 2623San Antonio, Texas, United States
Pantheon Clinical Research, LLCBountiful, Utah, United States
Local Institution - 1646Bennington, Vermont, United States
Local Institution - 1644Seattle, Washington, United States
Local Institution - 1654Spokane, Washington, United States
Local Institution - 2610Milwaukee, Wisconsin, United States
Local Institution - 2005Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 1001La Plata, Buenos Aires, Argentina
Local Institution - 1002Mar del Plata, Buenos Aires, Argentina
Local Institution - 2006Buenos Aires, Buenos Aires F.D., Argentina
Local Institution - 1006Rosario, Santa Fe Province, Argentina
Local Institution - 2004Buenos Aires, Argentina
Local Institution - 1003Buenos Aires, Argentina
Local Institution - 1004Córdoba, Argentina
Local Institution - 2000Córdoba, Argentina
Local Institution - 2002Córdoba, Argentina
Local Institution - 1005Córdoba, Argentina
Local Institution - 1000Córdoba, Argentina
Local Institution - 2003Córdoba, Argentina
Local Institution - 2001Mendoza, Argentina
Local Institution - 1051Brasília, Federal District, Brazil
Local Institution - 1052Curitiba, Paraná, Brazil
Local Institution - 1053Curitiba, Paraná, Brazil
Local Institution - 1058Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 1054Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 1057Campinas, São Paulo, Brazil
Local Institution - 1050Rio de Janeiro, Brazil
Local Institution - 1055São Paulo, Brazil
Local Institution - 1056São Paulo, Brazil
Local Institution - 1100Sofia, Sofia-Grad, Bulgaria
Local Institution - 1101Pleven, Bulgaria
Local Institution - 1103Razgrad, Bulgaria
Local Institution - 1102Varna, Bulgaria
Local Institution - 1153Hamilton, Ontario, Canada
Local Institution - 1155London, Ontario, Canada
Local Institution - 1151Toronto, Ontario, Canada
Local Institution - 1154Toronto, Ontario, Canada
Local Institution - 1152Whitby, Ontario, Canada
Local Institution - 2051Santiago, Santiago Metropolitan, Chile
Local Institution - 2052Santiago, Santiago Metropolitan, Chile
Local Institution - 2054Vitacura, Santiago Metropolitan, Chile
Local Institution - 2055Viña del Mar, Valparaiso, Chile
Local Institution - 2053Antofagasta, Chile
Local Institution - 1553Zagreb, City of Zagreb, Croatia
Local Institution - 1554Rijeka, Croatia
Local Institution - 1551Split, Croatia
Local Institution - 1552Varaždin, Croatia
Local Institution - 1550Zagreb, Croatia
Local Institution - 2107Olomouc, Olomouc Region, Czechia
Local Institution - 2100Prague, Praha 6, Czechia
Local Institution - 2106Prague, Praha 8, Czechia
Local Institution - 2103Brno, South Moravian, Czechia
Local Institution - 2101Choceň, Czechia
Local Institution - 2104Pilsen, Czechia
Local Institution - 2102Prague, Czechia
Local Institution - 2105Prague, Czechia
Local Institution - 2108Rychnov nad Kněžnou, Czechia
Local Institution - 2150Toulouse, Haute-Garonne, France
Local Institution - 2151Villeurbanne, Rhône, France
Local Institution - 2153Lille, France
Local Institution - 2156Limoges, France
Local Institution - 2157Montpellier, France
Local Institution - 2152Paris, France
Local Institution - 2155Strasbourg, France
Local Institution - 2201Düsseldorf, Germany
Local Institution - 2205Halle, Germany
Local Institution - 2206Westerstede, Germany
Local Institution - 1200Pátrai, Achaḯa, Greece
Local Institution - 1205Athens, Attica, Greece
Local Institution - 1202Athens, Attica, Greece
Local Institution - 1203Chaïdári, Attikí, Greece
Local Institution - 0027Athens, Greece
Local Institution - 1206Athens, Greece
Local Institution - 1207Athens, Greece
Local Institution - 1201Ioannina, Greece
Local Institution - 1204Thessaloniki, Greece
Local Institution - 2257Kalocsa, Bács-Kiskun county, Hungary
Local Institution - 2250Győr, Győr-Moson-Sopron, Hungary
Local Institution - 2254Gyöngyös, Heves County, Hungary
Local Institution - 2255Budapest, Hungary
Local Institution - 2251Budapest, Hungary
Local Institution - 2253Budapest, Hungary
Local Institution - 2252Debrecen, Hungary
Local Institution - 1251Hyderabad, Andhra Pradesh, India
Local Institution - 1255Ahmedabad, Gujarat, India
Local Institution - 1252Hyderabad, Telangana, India
Local Institution - 1254Varanasi, Uttar Pradesh, India
Local Institution - 1250Kolkata, West Bengal, India
Local Institution - 1256Delhi, India
Local Institution - 1253New Delhi, India
Local Institution - 2302Petch Tikva, IL, Israel
Local Institution - 2301Jerusalem, Israel
Local Institution - 2303Netanya, Israel
Local Institution - 2305Ramat Gan, Israel
Local Institution - 2300Ramat Gan, Israel
Local Institution - 2304Rishon Le'Tzion, Israel
Local Institution - 2351Naples, Campania, Italy
Local Institution - 2354Rome, Lazio, Italy
Local Institution - 2352Rome, Lazio, Italy
Local Institution - 2353Milan, Lombardy, Italy
Local Institution - 2350Pisa, PI, Italy
Local Institution - 2356Brescia, Italy
Local Institution - 2355Isernia, Italy
Local Institution - 2357Roma, Italy
Local Institution - 1301Hadano, Kanagawa, Japan
Local Institution - 1307Kawasaki, Kanagawa, Japan
Local Institution - 1304Sakai, Osaka, Japan
National Hospital Organization Hizen Psychiatric CenterKanzaki-Gun Yoshinogari-Cho, Saga-ken, Japan
Rainbow and Sea HospitalKaratsu-shi, Saga-ken, Japan
Local Institution - 1305Bunkyo-ku, Tokyo, Japan
Kuramitsu HospitalFukuoka, Japan
Okayama City General Medical Center Okayama City HospitalOkayama, Japan
Local Institution - 1308Shimotsuke-shi, Tochigi, Japan
Local Institution - 1355Saltillo, Coahuila, Mexico
Local Institution - 1356Guadalajara, Jalisco, Mexico
Local Institution - 1363Mexico City, Mexico City, Mexico
Local Institution - 1360Mexico City, Mexico City, Mexico
Local Institution - 1364Monterrey, Nuevo León, Mexico
Local Institution - 1350Monterrey, Nuevo León, Mexico
Local Institution - 1361Mexico City, Mexico
Local Institution - 1362San Luis Potosí City, Mexico
Local Institution - 1352Tlalnepantla, Mexico
Local Institution - 2450Poznan, Greater Poland Voivodeship, Poland
Local Institution - 2454Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Local Institution - 2456Chorzów, Poland
Local Institution - 2455Katowice, Poland
Local Institution - 2451Lublin, Poland
Local Institution - 2452Lublin, Poland
Local Institution - 2453Sochaczew, Poland
Local Institution - 1401Coimbra, Portugal
Local Institution - 1402Guimarães, Portugal
Local Institution - 1404Lisbon, Portugal
Local Institution - 1403Senhora da Hora, Portugal
Local Institution - 1400Torres Vedras, Portugal
Local Institution - 1450Bucharest, Bucharest, Romania
Local Institution - 1452Bucharest, Bucharest, Romania
Local Institution - 1453Bucharest, Bucharest, Romania
Local Institution - 1454Bucharest, Bucharest, Romania
Local Institution - 1455Bucharest, Bucharest, Romania
Local Institution - 1456Bucharest, Bucharest, Romania
Local Institution - 1458Bucharest, Bucharest, Romania
Local Institution - 1451Bucharest, Romania
Local Institution - 1459Bucharest, Romania
Local Institution - 1461Constanța, Romania
Local Institution - 1457Iași, Romania
Local Institution - 1460Sanpetru /Brasov, Romania
Local Institution - 1462Sibiu, Romania
Local Institution - 2401Incheon, Incheon Gwang'yeogsi, South Korea
Seoul National University HospitalSeoul, Seoul-teukbyeolsi [Seoul], South Korea
Local Institution - 2403Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Local Institution - 2406Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Local Institution - 2400Deagu, Taegu-Kwangyǒkshi, South Korea
Local Institution - 2409Incheon, South Korea
Local Institution - 2402Seoul, South Korea
Gangnam Severance Hospital, Yonsei University Health SystemSeoul, South Korea
Local Institution - 2405Seoul, South Korea
The Catholic University of Korea, Yeouido St.Mary's HospitalSeoul, South Korea
Local Institution - 1510Getxo, Bizkaia, Spain
Local Institution - 1509Elche (alicante), Spain
Local Institution - 1508Madrid, Spain
Local Institution - 1505Madrid, Spain
Local Institution - 0003Málaga, Spain
Local Institution - 1502Málaga, Spain
Local Institution - 1507Pamplona, Spain
Local Institution - 1500Salamanca, Spain
Local Institution - 1503Seville, Spain
Local Institution - 1504Terrassa, Spain
Local Institution - 1506Valladolid, Spain
Local Institution - 1501Zaragoza, Spain
Local Institution - 1753Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Local Institution - 1751Tainan, Taiana, Taiwan
Local Institution - 1754Taipei, Taiwan
Local Institution - 1750Taipei, Taiwan
Local Institution - 1752Taoyuan, Taiwan
Local Institution - 2555Smila, Cherkasy Oblast, Ukraine
Local Institution - 2554Dnipro, Dnipropetrovsk Oblast, Ukraine
Local Institution - 2566Hlevakha, Kyiv Oblast, Ukraine
Local Institution - 2552Lviv, Lviv Oblast, Ukraine
Local Institution - 2558Lviv, Lviv Oblast, Ukraine
Local Institution - 2569Lviv, Lviv Oblast, Ukraine
Local Institution - 2567Oleksandrivka, Odesa Oblast, Ukraine
Local Institution - 2551Vinnytsia, Vinnytsia Oblast, Ukraine
Local Institution - 2556Hlevakha, Ukraine
Local Institution - 2550Kropyvnytskyi, Ukraine
Local Institution - 2565Kyiv, Ukraine
Local Institution - 2553Kyiv, Ukraine
Local Institution - 2568Odesa, Ukraine
Local Institution - 2557Poltava, Ukraine
Local Institution - 2559Skarzhyntsi, Ukraine
Local Institution - 2505Preston, Lancashire, United Kingdom
Surrey and Borders Partnership NHS Foundation TrustChertsey, Surrey, United Kingdom
Local Institution - 2502Cambridge, United Kingdom
Local Institution - 2501London, United Kingdom
Local Institution - 2500London, United Kingdom
Local Institution - 2510Motherwell, United Kingdom
Cornwall Partnership NHS Foundation TrustRedruth, United Kingdom
Local Institution - 2504Sheffield, United Kingdom
Local Institution - 2509Stafford, United Kingdom
Local Institution - 2503Wolverhampton, United Kingdom