TerminatedPhase 3

A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

NCT04241068

What is this trial?

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Where and how to apply

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, United States

+296 additional locations

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Quick facts

Start date: 2020-03-02
Enrollment: 1,696 participants
Sponsor: Biogen
Purpose: treatment

Locations (297)

University of Alabama at BirminghamBirmingham, Alabama, United States
Banner Alzheimer's InstitutePhoenix, Arizona, United States
Dignity HealthPhoenix, Arizona, United States
Banner Sun Health Research InstituteSun City, Arizona, United States
Center for NeurosciencesTucson, Arizona, United States
Neurology Center of North Orange CountyFullerton, California, United States
UCI MINDIrvine, California, United States
University of California San Diego Medical CenterLa Jolla, California, United States
Senior Clinical Trials, Inc.Laguna Hills, California, United States
USC Keck School of MedicineLos Angeles, California, United States
Mary S. Easton Center for Alzheimer's Disease Research, UCLALos Angeles, California, United States
Pacific Neuroscience Medical GroupOxnard, California, United States
Stanford Hospital and ClinicsPalo Alto, California, United States
Anderson Clinical ResearchRedlands, California, United States
Pacific Research Network, IncSan Diego, California, United States
UCSF - Memory and Aging CenterSan Francisco, California, United States
Syrentis Clinical ResearchSanta Ana, California, United States
California Neuroscience Research Medical Group Inc.Sherman Oaks, California, United States
University of Colorado DenverAurora, Colorado, United States
IMMUNOe International Research CentersCentennial, Colorado, United States
Yale UniversityFairfield, Connecticut, United States
InvicroNew Haven, Connecticut, United States
Yale University School Of MedicineNew Haven, Connecticut, United States
Research Center for Clinical Studies, Inc.Norwalk, Connecticut, United States
Georgetown University Clinical Research Unit (CRU)Washington D.C., District of Columbia, United States
JEM ResearchAtlantis, Florida, United States
Bradenton Research Center, IncBradenton, Florida, United States
Brain Matters ResearchDelray Beach, Florida, United States
Neuropsychiatric Research Center of Southwest FloridaFort Myers, Florida, United States
Infinity Clinical Research, LLCHollywood, Florida, United States
Jacksonville Center for Clinical ResearchJacksonville, Florida, United States
Mayo Clinic in FloridaJacksonville, Florida, United States
University of MiamiMiami, Florida, United States
Miami Jewish Health System, IncMiami, Florida, United States
Renstar Medical ResearchOcala, Florida, United States
Accelerated Enrollment Solutions (AES)Orlando, Florida, United States
Clinical Neuroscience Solutions, Inc.Orlando, Florida, United States
Accelerated Enrollment Solutions (AES)Orlando, Florida, United States
Palm Beach Neurological CenterPalm Beach Gardens, Florida, United States
Quantum Laboratories Inc.Pompano Beach, Florida, United States
Axiom Clinical Research of FloridaTampa, Florida, United States
Stedman Clinical Trials, LLCTampa, Florida, United States
USF Health Byrd InstituteTampa, Florida, United States
Meridien ResearchTampa, Florida, United States
Premiere Research InstituteWest Palm Beach, Florida, United States
Cleveland Clinic Florida - WestonWeston, Florida, United States
Emory University Cognitive Neurology Clinic & ADRCAtlanta, Georgia, United States
Medical Research Health and Education Foundation, IncColumbus, Georgia, United States
NeuroStudies.net, LLCDecatur, Georgia, United States
Alexian Brothers Medical Center - Neuroscience Research InstituteElk Grove Village, Illinois, United States
Advocate Lutheran General HospitalPark Ridge, Illinois, United States
Fort Wayne Neurological CenterFort Wayne, Indiana, United States
Indiana University School of MedicineIndianapolis, Indiana, United States
Josephson, Wallack, Munshower Neurology, P.C.Indianapolis, Indiana, United States
University of Kansas Medical Center Research Institute, Inc.Fairway, Kansas, United States
Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.Wichita, Kansas, United States
Baptist Health LexingtonLexington, Kentucky, United States
McLean HospitalBelmont, Massachusetts, United States
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United States
Brigham and Women's Hospital Department of NeurologyBoston, Massachusetts, United States
ActivMed Practices & Research, Inc.Methuen, Massachusetts, United States
Boston Center for MemoryNewton, Massachusetts, United States
Donald S. Marks, M.D., P.C.Plymouth, Massachusetts, United States
Mayo ClinicRochester, Michigan, United States
Hattiesburg Clinic, PAHattiesburg, Mississippi, United States
Washington UniversitySt Louis, Missouri, United States
Cleveland Clinic Lou Ruvo Center for Brain HealthLas Vegas, Nevada, United States
Las Vegas Medical ResearchLas Vegas, Nevada, United States
ActivMed Practices & Research, Inc.Portsmouth, New Hampshire, United States
Advanced Memory Research Inst. of NJ, PCToms River, New Jersey, United States
Albany Medical CollegeAlbany, New York, United States
Empire Neurology, PCLatham, New York, United States
New York University Medical Center PRIMENew York, New York, United States
Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC)New York, New York, United States
Mount Sinai School of MedicineNew York, New York, United States
University of RochesterRochester, New York, United States
AMC Research, LLCCharlotte, North Carolina, United States
Raleigh Neurology AssociatesRaleigh, North Carolina, United States
Gastroenterology Associates of the PiedmontWinston-Salem, North Carolina, United States
Wake Forest Baptist HealthWinston-Salem, North Carolina, United States
Cleveland Clinic FoundationCleveland, Ohio, United States
Ohio State University Wexner Medical CenterColumbus, Ohio, United States
Lynn Health Science InstituteOklahoma City, Oklahoma, United States
Lehigh Center for Clinical Research, LLCAllentown, Pennsylvania, United States
The Clinical Trial Center, LLCJenkintown, Pennsylvania, United States
Penn Memory CenterPhiladelphia, Pennsylvania, United States
University of PittsburghPittsburgh, Pennsylvania, United States
Northeastern Pennsylvania Memory and Alzheimer's CenterWilkes-Barre, Pennsylvania, United States
Rhode Island Mood & Memory Research InstituteEast Providence, Rhode Island, United States
Rhode Island HospitalProvidence, Rhode Island, United States
Butler HospitalProvidence, Rhode Island, United States
Roper St. Francis HealthcareCharleston, South Carolina, United States
Medical University of South Carolina (MUSC)Charleston, South Carolina, United States
Neurology Clinic, PCCordova, Tennessee, United States
Senior Adult Specialty ResearchAustin, Texas, United States
UT Southwestern Medical CenterDallas, Texas, United States
Baylor College of MedicineHouston, Texas, United States
Clinical Trial NetworkHouston, Texas, United States
University of Utah Health Sciences CenterSalt Lake City, Utah, United States
The Memory ClinicBennington, Vermont, United States
National Clinical Research Inc.-RichmondRichmond, Virginia, United States
University of Washington Medical CentreSeattle, Washington, United States
Kingfisher Cooperative, LLCSpokane, Washington, United States
Medical College of Wisconsin, Inc.Milwaukee, Wisconsin, United States
The Prince Charles HospitalChermside, New South Wales, Australia
St Vincent's Hospital SydneyDarlinghurst, New South Wales, Australia
Central Coast Neurosciences Research (Erina)Erina, New South Wales, Australia
KaRa Institute of Neurological DiseasesMacquarie Park, New South Wales, Australia
Box Hill HospitalBox Hill, Victoria, Australia
Austin HealthHeidelberg West, Victoria, Australia
Royal Melbourne HospitalParkville, Victoria, Australia
Australian Alzheimer's Research FoundationNedlands, Western Australia, Australia
LKH - Universitaetsklinikum GrazGraz, Austria
Christian-Doppler-Klinik - Universitätsklinikum SalzburgSalzburg, Austria
AKH - Medizinische Universität WienVienna, Austria
AZ KlinaBrasschaat, Belgium
AZ Sint-JanBruges, Belgium
Universitair Ziekenhuis BrusselBrussels, Belgium
Universitair Ziekenhuis GentGhent, Belgium
AZ GroeningeKortrijk, Belgium
UZ LeuvenLeuven, Belgium
AZ DeltaRoeselare, Belgium
University of Calgary - Heritage Medical Research ClinicCalgary, Alberta, Canada
The Medical Arts Health Research GroupKamloops, British Columbia, Canada
The Medical Arts Health Research GroupPenticton, British Columbia, Canada
UBC HospitalVancouver, British Columbia, Canada
Medical Arts Health Research GroupWest Vancouver, British Columbia, Canada
True North Clinical Research - Halifax Inc.Halifax, Nova Scotia, Canada
True North Clinical ResearchKentville, Nova Scotia, Canada
St. Joseph's HC- Parkwood InstituteLondon, Ontario, Canada
Bruyere Continuing CareOttawa, Ontario, Canada
Kawartha Centre - Redefining Healthy AgingPeterborough, Ontario, Canada
Toronto Memory Program (Neurology Research Inc.)Toronto, Ontario, Canada
Toronto Sunnybrook HospitalToronto, Ontario, Canada
Toronto Western HospitalToronto, Ontario, Canada
Clinique de la Memoire de l'OutaouaisGatineau, Quebec, Canada
Institut et Clinique MoCAGreenfield Park, Quebec, Canada
Montreal Neurological Institute Clinical Research UnitMontreal, Quebec, Canada
CHU de Quebec - Hôpital de l' Enfant JésusQuébec, Canada
CCBR - Ålborg - DKAalborg, Denmark
Danish Dementia Research CentreCopenhagen, Denmark
CCBR - Vejle - DKVejle, Denmark
Terveystalo RuoholahtiHelsinki, Finland
Itä-Suomen yliopisto, AivotutkimusyksikköKuopio, Finland
CRST, Clinical Research Services TurkuTurku, Finland
CHU Strasbourg - Hôpital HautepierreStrasbourg, Bas Rhin, France
Hôpital de la TimoneMarseille, Bouches-du-Rhône, France
Groupe Hospitalier Pellegrin - Hôpital PellegrinBordeaux, Gironde, France
Hopital PurpanToulouse, Haute Garonne, France
Hôpital La GraveToulouse, Haute Garonne, France
Hopital Gui de ChauliacMontpellier, Herault, France
CHU Rennes - PontchaillouRennes, Ille Et Vilaine, France
CHU Nantes - Hopital Nord LaënnecNantes, Loire Atlantique, France
CHU Reims - Hôpital Maison BlancheReims, Marne, France
CHU Lille - Hopital Roger SalengroLille, Nord, France
Hôpital LariboisièreParis, Paris, France
CHU de Lyon - Hopital Neurologique Pierre WertheimerBron, Rhone, France
Hôpital des ChapennesVilleurbanne, Rhone, France
Groupe Hospitalier Pitie-SalpetriereParis, France
Hôpital BrocaParis, France
Studienzentrum fur Neurologie und PsychiatrieBöblingen, Baden-Wurttemberg, Germany
ISPG - Institut fuer Studien zur Psychischen GesundheitMannheim, Baden-Wurttemberg, Germany
mind mvz GmbHStuttgart, Baden-Wurttemberg, Germany
Neuropoint StudienzentrumUlm, Baden-Wurttemberg, Germany
Universitaetsklinikum UlmUlm, Baden-Wurttemberg, Germany
Klinikum Bayreuth GmbH- Hohe WarteBayreuth, Bavaria, Germany
Bezirkskrankenhaus GuenzburgGünzburg, Bavaria, Germany
Klinikum rechts der Isar der TU MuenchenMunich, Bavaria, Germany
Institut fuer Schlaganfall- und Demenzforschung (ISD)München, Bavaria, Germany
Neuropraxis Muenchen SuedUnterhaching, Bavaria, Germany
Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. GErbach im Odenwald, Hesse, Germany
Neurologische Gemeinschaftspraxis KasselKassel, Hesse, Germany
Klinische Forschung Hannover-Mitte GmbHHanover, Lower Saxony, Germany
Universitaetsklinikum Aachen AOeRAachen, North Rhine-Westphalia, Germany
Neurozentrum BielefeldBielefeld, North Rhine-Westphalia, Germany
Universitaetsklinikum KoelnCologne, North Rhine-Westphalia, Germany
Universitaetsklinikum Duesseldorf AoeRDüsseldorf, North Rhine-Westphalia, Germany
Zentrum f. Neurologisch- Psychiatrische Studien und BegutachtungSiegen, North Rhine-Westphalia, Germany
Klinikum Altenburger Land GmbHAltenburg, Thuringia, Germany
Emovis GmbHBerlin, Germany
Neurologie im Tempelhofer HafenBerlin, Germany
Charite Universitaetsmedizin Berlin - Campus Berlin BuchBerlin, Germany
Ospedale degli InfermiPonderano, Biella, Italy
Azienda Ospedaliera Card. G. PanicoTricase, Lecce, Italy
ASST di MonzaMonza, Milano, Italy
Fondazione Istituto G.Giglio di CefalùCefalù, Palermo, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)Brescia, Italy
Azienda Ospedaliero Universitaria San MartinoGenova, Italy
Ospedale San RaffaeleMilan, Italy
Fondazione IRCCS Istituto Neurologico Carlo BestaMilan, Italy
AOU dell'Università degli studi della Campania Luigi VanvitelliNaples, Italy
Azienda Ospedaliera e Universitaria di PerugiaPerugia, Italy
Azienda Ospedaliero Universitaria PisanaPisa, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La SapienzaRoma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCSRoma, Italy
Fondazione Santa Lucia IRCCSRoma, Italy
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'AragonaSalerno, Italy
A.O.U. Senese Policlinico Santa Maria alle ScotteSiena, Italy
Research SiteObu-shi, Aichi-ken, Japan
Research SiteChiba, Chiba, Japan
Research SiteChiba, Chiba, Japan
Research SiteInzai-shi, Chiba, Japan
Research SiteToon-shi, Ehime, Japan
Research SiteFukuoka, Fukuoka, Japan
Research SiteKurume-shi, Fukuoka, Japan
Research SiteAizu-Wakamatsu, Fukushima, Japan
Research SiteOtake-shi, Hiroshima, Japan
Research SiteAsahikawa-shi, Hokkaido, Japan
Research SiteSapporo, Hokkaido, Japan
Research SiteAmagasaki-shi, Hyōgo, Japan
Research SiteHimeji-shi, Hyōgo, Japan
Research SiteHimeji-shi, Hyōgo, Japan
Research SiteKobe, Hyōgo, Japan
Research SiteKita-gun, Kagawa-ken, Japan
Research SiteKamakura-shi, Kanagawa, Japan
Research SiteKyoto, Kyoto, Japan
Research SiteKyoto, Kyoto, Japan
Research SiteTsu, Mie-ken, Japan
Research SiteTogitsu, Nagasaki, Japan
Research SiteNagaoka-shi, Niigata, Japan
Research SiteYufu-shi, Oita Prefecture, Japan
Research SiteKurashiki-shi, Okayama-ken, Japan
Research SiteOkayama, Okayama-ken, Japan
Research SiteTsukuba, Okayama-ken, Japan
Research SiteOsaka, Osaka, Japan
Research SiteSuita-shi, Osaka, Japan
Research SiteIruma-gun, Saitama, Japan
Research SiteKasukabe-shi, Saitama, Japan
Research SiteShizuka-shi, Shizuoka, Japan
Research SiteShizuoka, Shizuoka, Japan
Research SiteBunkyō City, Tokyo-To, Japan
Research SiteKiyose-shi, Tokyo-To, Japan
Research SiteKodaira-shi, Tokyo-To, Japan
Research SiteYamagata, Yamagata, Japan
Brain Research CenterAmsterdam, Netherlands
Amphia Ziekenhuis, MolengrachtBreda, Netherlands
Erasmus Medisch CentrumRotterdam, Netherlands
Podlaskie Centrum PsychogeriatriiBialystok, Poland
PALLMED Sp. z o.o.Bydgoszcz, Poland
Klinika Psychiatrii Doroslych UCKGdansk, Poland
Novo-Med Zielinski i wspolnicy Sp. j.Katowice, Poland
SPZOZ Centralny Szpital Kliniczny UM w LodziLodz, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4 w LublinieLublin, Poland
NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.Poznan, Poland
Neuro-Care Gabriela KlodowskaSiemianowice Śląskie, Poland
Centrum Medyczne SeniorSopot, Poland
Osrodek Badan Klinicznych EUROMEDISSzczecin, Poland
Centrum Medyczne NeuroProtectWarsaw, Poland
NZOZ Wroclawskie Centrum AlzheimerowskieWroclaw, Poland
Hospital de BragaBraga, Portugal
Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de CoimbraCoimbra, Portugal
Hospital Beatriz ÂngeloLoures, Portugal
CNS-Campus Neurologico SeniorTorres Vedras, Portugal
Inha University HospitalIncheon, Gyeonggi-do, South Korea
Seoul National University Bundang HospitalSeongnam-si, Gyeonggi-do, South Korea
Gachon University Gil Medical CenterIncheon, South Korea
Konkuk University Medical CenterSeoul, South Korea
Asan Medical CenterSeoul, South Korea
Samsung Medical CenterSeoul, South Korea
Hospital General Universitario de ElcheElche, Alicante, Spain
Hospital Universitario Reina SofiaCórdoba, Córdoba, Spain
Policlinica GipuzkoaDonostia / San Sebastian, Guipuzcoa, Spain
Clinica Universidad de NavarraPamplona, Navarre, Spain
CAE OroituGetxo, Vizcaya, Spain
Hospital del MarBarcelona, Spain
Hospital de la Santa Creu i Sant PauBarcelona, Spain
Fundacio ACEBarcelona, Spain
Hospital Clinic de BarcelonaBarcelona, Spain
Hospital Universitari de Santa MariaLleida, Spain
Complejo Hospitalario Ruber Juan BravoMadrid, Spain
Hospital Victoria EugeniaSeville, Spain
Hospital Universitario Dr. PesetValencia, Spain
Hospital Universitari i Politecnic La FeValencia, Spain
Skånes UniversitetssjukhusMalmö, Sweden
Sahlgrenska Universitetssjukhuset, Mölndal SjukhusMölndal, Sweden
Karolinska Universitetssjukhuset, HuddingeStockholm, Sweden
Akademiska SjukhusetUppsala, Sweden
Spitalzentrum BielBiel/Bienne, Switzerland
Hôpitaux Universitaires de Geneve- HUGGeneva, Switzerland
Centre Hospitalier Universitaire VaudoisLausanne, Switzerland
Ospedale Regionale di LuganoLugano, Switzerland
Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus SchlierenSchlieren, Switzerland
Changhua Christian Medical Foundation Changhua Christian HospitalChanghua, Taiwan
Kaohsiung Chang Gung Memorial HospitalKaohsiung City, Taiwan
National Cheng Kung University HospitalTainan, Taiwan
Taipei Veterans General HospitalTaipei, Taiwan
Chang Gung Memorial Hospital, LinkouTaoyuan City, Taiwan
Re:Cognition Health Ltd (London)London, Greater London, United Kingdom
Charing Cross HospitalLondon, Greater London, United Kingdom
The National Hospital for Neurology and Neurosurgery CentreLondon, Greater London, United Kingdom
Manchester Royal InfirmaryManchester, Greater Manchester, United Kingdom
The University of EdinburghEdinburgh, Lothian Region, United Kingdom
The RICE CentreBath, Somerset, United Kingdom
Queen Elizabeth University Hospital CampusGlasgow, Strathclyde, United Kingdom
Glasgow Memory Clinic LtdMotherwell, Strathclyde, United Kingdom
Ninewells HospitalDundee, Tayside Region, United Kingdom
Newcastle UniversityNewcastle upon Tyne, Tyne & Wear, United Kingdom