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Active, not recruitingPhase 2

Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees

The study will test a new approach to the design and implementation of socket and liner technology in individuals who lost a lower limb secondary to diabetes mellitus type II (herein referred to as dysvascular amputees). The technology-base

Boston, Massachusetts, United States
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CompletedPhase 1

Novel Type 2 Diabetes Mellitus Preventive Therapies

Over the past two decades, type 2 diabetes mellitus (T2DM) has emerged from relative obscurity to become one of the most serious complications of obesity in Hispanic obese populations, especially among those with a family history of T2DM. F

Boston, Massachusetts, United States
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Not yet recruitingN/A

Voice-activated and Touchscreen-controlled Smart Speaker Intervention for Older Adults With Poorly Controlled Type 2 Diabetes

This is a pre-post pilot study that will test the feasibility and acceptability of a health educator delivered diabetes education and skills training intervention using a voice-activated, touch screen controlled, smart speaker. We will enro

Multiple locations
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CompletedPhase 2

Lanifibranor in Patients With Type 2 Diabetes & Nonalcoholic Fatty Liver Disease

The primary aim is to establish the safety, efficacy and mechanism of action of lanifibranor in patients with type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD). Specifically, to determine if lanifibranor decreases intrahep

Gainesville, Florida, United States
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CompletedN/A

FAMS Mobile Health Intervention for Diabetes Self-care Support

This study evaluates a family-focused mobile phone-delivered intervention, called FAMS (Family-focused Add-on for Motivating Self-care), in supporting adults with type 2 diabetes in their self-management relative to a control group. The goa

Nashville, Tennessee, United States
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UnknownPhase 4

Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus

Although intensive medical treatment of diabetes has clearly been demonstrated to be worthwhile, it has not been a total success in diabetes treatment for a variety of reasons including lack of response to medication. Diabetes has been well

Taoyuan, Taiwan
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RecruitingN/A

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

IRIS-CKD is an implementation study to improve guideline-recommended screening of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.

Birmingham, Alabama, United States+6 more
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UnknownN/A

Diabetes Companion App for Adults With Diabetes and Their Carers

Diabetes self-management support, education, and training are increasingly being delivered through digital technology such as mobile phones. This protocol aims to evaluate the effectiveness of GLOW, a diabetes companion app with a conversat

Singapore, Singapore+1 more
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CompletedPhase 3

Safety and Efficacy of Exenatide as Monotherapy

This Phase 3 trial is designed to compare the effects of twice-daily exenatide and twice-daily placebo with respect to glycemic control in drug-naive patients with type 2 diabetes treated with diet and exercise.

Idaho Falls, Idaho, United States+18 more
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Completed

An Observational Study of Efficacy and Safety of Modern Insulin in Diabetes Patients Switched From Anti-diabetic Treatment

This study is conducted in Asia. The aim of this observational study is to evaluate the safety and efficacy of modern insulins after switch from any other anti-diabetic treatment under normal clinical conditions in the Gulf countries.

Riyadh, Saudi Arabia
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Not yet recruitingN/A

Advance Health Mobile APP for the Self Management of Diabetes type2

Digital health using mobile health (mHealth) tools, such as telehealth and text messaging, and or mobile Apps can improve blood glucose levels in patients with type 2 diabetes. This intervention is designed to improve self-management of dia

Lahore, Punjab Province, Pakistan
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CompletedPhase 3

Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Participants With Type 2 Diabetes Mellitus (MK-0431-251)

The primary objectives of this study are to determine if sitagliptin treatment is not inferior to that of glimepiride as measured by the change in baseline hemoglobin A1C (HbA1C) after 30 weeks of treatment, and if sitagliptin treatment res

Multiple locations
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UnknownN/A

Lifestyle Monitoring and Coaching Using the Mobile DIAMETER Application in Secondary Care

Type 2 Diabetes Mellitus (T2DM) is a major chronic lifestyle-related disorder with a significant impact on quality and costs of care. As patients with T2DM often have insufficient knowledge about proper self-management and are insufficientl

Almelo, Overijssel, Netherlands
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CompletedPhase 3

Safety and Efficacy of Dapagliflozin in Triple Therapy to Treat Subjects With Type 2 Diabetes

The purpose of this study is to learn if BMS-512148 (Dapagliflozin) as part of a triple combination therapy can improve (decrease) hemoglobin A1c in patients with type 2 diabetes after 24 weeks of treatment compared to a 2 drug oral antidia

Birmingham, Alabama, United States+65 more
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CompletedPhase 3

A Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Oral Monotherapy Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus

This study is designed to examine the long term safety and efficacy of weekly subcutaneously injected albiglutide in combination with a single oral antidiabetic drug for 52 weeks in Japanese subjects with type 2 diabetes mellitus.

Aichi, Japan+48 more
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UnknownN/A

The Effect of Different Training Programs on Patients With Chronic Diseases

A total of 240 hypertensive subjects aged 40-69 years (including 126 patients complicated with diabetes) will be included in a few communities in Beijing, and will be divided into 3 groups according to the individual wishes of the subjects:

Beijing, Beijing Municipality, China
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CompletedN/A

Mobile Augmented Reality Learning On Insulin Administration Knowledge And Skills Of Patients

The goal of this study to determine the effectiveness of insulin administration with augmented reality on increasing the knowledge and skills of patients newly diagnosed with type 2 diabetes on insulin administrations, determining patients'

Izmir, Turkey (Türkiye)
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UnknownN/A

Physical Activity and CVD in Adolescents With Type 2 Diabetes

The main research questions for this study are: (1) Is delivering a resiliency-informed behavioural intervention designed to increase physical activity (PA) feasible for adolescents living with Type 2 Diabetes (T2D)? and (2) What is the exp

Winnipeg, Manitoba, Canada
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CompletedPhase 2

Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)

This study is a Phase II, placebo-controlled, double-blind, randomized trial in 480 participants with atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (for example, diabetes and familial hypercholesterolemia) and ele

Jacksonville, Florida, United States+53 more
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CompletedPhase 4

Testosterone Replacement in Men With Diabetes and Obesity

The purpose of this study is to examine the effect of having testosterone deficiency in men with diabetes and with obesity. The study will also evaluate the effect of testosterone therapy.

Williamsville, New York, United States
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