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UnknownN/A

Effectiveness of Intensive Rehabilitation in Advanced Stages of Parkinson's Disease.

this study is aimed to evaluate the effectiveness of an Multidisciplinary Intensive Rehabilitation Treatment in Advanced Stages of Parkinson's Disease. In the last years, several evidences highlighted the need of a multidisciplinary and int

Gravedona Ed Uniti, Como, Italy
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WithdrawnN/A

Efficacy of Probiotics for Parkinson Disease (PD)

In previous clinical studies, PS128 has been reported to ameliorate motor deficits in Parkinson's disease (PD). PS23 has been reported to delay some age-related disorders.

Changhua, Taiwan
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CompletedPhase 2

Dose-Finding Safety Study of BIIB014 in Early-Stage Parkinson's Disease

The main purpose of this study is to determine the safety of BIIB014 and how well BIIB014 is tolerated when given at different doses to patients with early-stage Parkinson's Disease. This study will also explore: * How BIIB014 is affected

Ashkelon, Israel+9 more
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RecruitingPhase 2

Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

The study is a longitudinal, multi-center study to assess progression of \[18F\] AV-133 imaging in Prodromal PD participants. Participants will be followed for up to 24 months.

New Haven, Connecticut, United States+7 more
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CompletedN/A

Evaluation of the Uses of a Digital-assisted Self-rehabilitation Device (TELE-PARK)

Evaluate the use by the patient and his family and professional environment of a self-rehabilitation device with follow-up in tele-rehabilitation in people with Parkinson's disease taking into account the different actors within a health ar

Rennes, Brittany Region, France
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RecruitingN/A

Impact of Frequency-specific Subthalamic Nucleus Subregion Stimulation on Inhibitory Control in Parkinson's Disease

The core symptoms of Parkinson's disease (PD) include both motor and non-motor symptoms. Cognitive impairment is one of the most common non-motor symptoms in PD patients, with approximately 30% of patients exhibiting cognitive dysfunction a

Beijing, Beijing Municipality, China
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CompletedPhase 2

Pioglitazone in Early Parkinson's Disease

This is a multi-center, double-blind, placebo controlled clinical trial of two dosages of oral pioglitazone (15 milligram(mg) and 45 milligram (mg)) for safety, tolerability, and futility. Subjects who are on stable dose of rasagiline 1 mg/

Birmingham, Alabama, United States+37 more
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TerminatedPhase 2

Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease

A phase II double blind trial to evaluate the effects of the AMPA, glutamte antagonist, topiramate on levodopa-induced dyskinesia in Parkinson's disease

Toronto, Ontario, Canada
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CompletedN/A

Neuroplasticity in Parkinson´s Disease After Training

This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease. The main hypothesis is that highly challenging exercise will lead to greater gait and balance a

Huddinge, Sweden
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Recruiting

Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:

Real-World Participants Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease

Aliso Viejo, California, United States+4 more
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CompletedPhase 1

Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Carbidopa

To investigate the effect of three single oral doses of BIA 9-1067 (25 mg, 50 mg and 100 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled-release levodopa/carbidopa 100/25 mg (Sinemet® C

Mount Royal, Quebec, Canada
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CompletedPhase 3

Efficacy of Isradipine in Early Parkinson Disease

The purpose of the study is to determine whether treatment with isradipine is effective in slowing the progression of Parkinson disease disability.

Birmingham, Alabama, United States+53 more
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Not yet recruitingPhase 1 / Phase 2

Sustained Release Oral Formulation For Treatment Of Parkinsons Disease

LD/CD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material. The assembly is placed in the oral/buccal cavity (between cheek and gum of lower jaw) and delivers continuous

Minneapolis, Minnesota, United States
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CompletedPhase 4

Long-Term Effects of Amantadine in Parkinsonian (AMANDYSK)

This is a French national trial, conducted using a double-blind, placebo-controlled, randomised design involving 7 centers and 80 patients of both sexes. The primary objective of the trial is to evaluate the effects of the interruption of a

Aix-en-Provence, France+4 more
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Unknown

Figure-of-Eight Walk Test in Parkinson

The aim of study is to assess validity and reliability of Figure-of-Eight Walk Test in people with Parkinson's Disease

Ankara, Turkey (Türkiye)
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Recruiting

Monoamine Oxidase B PET/CT in Various MAO-B-Related Disease

To evaluate the potential usefulness of 18F-FPyCO/SMBT-1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-B-related disease patients.

Hefei, Anhui, China+1 more
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CompletedPhase 3

Safety, Tolerability, and Efficacy of Donepezil (Aricept) in Parkinson' s Disease (PD) Patients With Dementia

The purpose of this study is to evaluate the safety, tolerability, and efficacy of donepezil (Aricept) in Parkinson's Disease (PD) patients with dementia.

Bath, Canterbury, United Kingdom
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CompletedN/A

Online Cognitive Behavioral Therapy for Depressive Symptoms in Parkinson's Disease

More than 1 million people in Europe suffer from Parkinson's disease (PD), a brain disorder manifesting with a motor syndrome and several non-motor features. Neuropsychiatric symptoms, like anxiety and depression, are common in patients wit

Stavanger, Norway
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Completed

Retrospective, Non-significant Risk, Deep Brain Stimulation (DBS) Care Management Software Feasibility Study

To evaluate DBS device settings and match with the features of the DBS care management software.

La Jolla, California, United States+1 more
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CompletedPhase 1

Lu AF82422 in Healthy Non-Japanese and Japanese Subjects and in Patients With Parkinson's Disease

The purpose of this study is to investigate the safety of a single dose of Lu AF82422, how well it is tolerated, how the drug effects the body and what the body does to the drug in healthy non-Japanese and Japanese subjects and in patients

Glendale, California, United States+3 more
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