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Unknown

A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients

This is a longitudinal study in healthy 1st degree relatives of patients with Parkinson's Disease (PD) carriers of a genetic mutation in genes that are known to increase the risk for PD. The purpose of this study is to explore the associati

Tel Aviv, Israel
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Active, not recruitingN/A

Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease

Parkinson's disease (PD) is a difficult to treat condition that impairs mobility and thinking. It is not fully treated by drugs and surgery.

Decatur, Georgia, United States
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TerminatedPhase 2 / Phase 3

Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy

This open-label study is designed to assess the long-term safety and tolerability of dipraglurant in PD patients for up to 52 weeks (at doses of 150-300 mg per day) for patients that have completed an Addex sponsored double-blind clinical t

Augusta, Georgia, United States+6 more
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Unknown

Long-term Safety and Effectiveness of Levodopa-carbidopa Intestinal Gel Infusion

Levodopa-carbidopa intestinal gel (LCIG) infusion has demonstrated to improve motor fluctuations. The aim of this study is to assess the long-term safety and effectiveness of LCIG infusion in advanced Parkinson's disease (PD) patients with

Barcelona, Spain
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UnknownN/A

Cycling Deep Brain Stimulation on Parkinson's Disease Gait

Our hypothesis is that cycling DBS stimulation would be superior or non-inferior to regular DBS stimulation in Parkinson's disease patients with gait impairment. The objective of this study is compare gait disorders in patients with Parkins

São Paulo, São Paulo, Brazil
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CompletedN/A

MENTAL PRACTICE IN MOTOR LEARNING OF BRUSHING AND PARKINSON DISEASE

Parkinson's disease (PD) is characterized by dopaminergic neurons degeneration of the substantia nigra, in the midbrain, resulting in the presence of motor disorders, such as tremor, rigidity, bradykinesia, and postural instability. Researc

Multiple locations
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Completed

LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers

The goals of this study are 1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD 2.

Beijing, China
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Unknown

Exploring Emotional Intelligence and Cognitive Flexibility in Anorexia Nervosa and Parkinson's Disease.

The main aim of this study is to demonstrate how disorders characterized by different types of "inflexibility", cognitive-affective type for Anorexia nervosa and motor one for Parkinson's disease, have an impact on how emotional stimuli are

Oggebbio, Italy
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RecruitingN/A

Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease

This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, slee

São Paulo, São Paulo, Brazil
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TerminatedN/A

Sensor-supported Classification of Gait Patterns in Everyday Movement of Patients With Parkinson's Disease

Within this study we conduct long-term measurements on Parkinson patients using a three sensor IMU setup: one sensor is located at the wrist, one sensor at the belt/ in the pocket and one sensor is worn as a pendant. Before and after each l

Aachen, North Rhine-Westphalia, Germany
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RecruitingN/A

Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders

This clinical trial aims to evaluate whether individualized targeted repetitive transcranial magnetic stimulation (rTMS) can improve motor and non-motor symptoms in patients with parkinsonian disorders. The main question it aims to answer i

Beijing, Beijing Municipality, China
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UnknownPhase 2

Effect of Folic Acid in Levodopa Treated Parkinson's Disease Patients

This is a prospective single center, randomized, double-blind, 2 arm placebo-controlled study in subjects with Parkinson's disease receiving levodopa .The patients will be randomized to receive tablet Folic Acid 10 mg per day or placebo for

Dhaka, Bangladesh
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WithdrawnPhase 2

A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson Patients

The study team proposes to treat Parkinson's patients with gait difficulty with multidisciplinary approach of medications. Single medication treatment, such as the use of cholinergic-boosting anti-dementia medication targeting cholinergic d

Chicago, Illinois, United States
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CompletedN/A

Mindfulness and Yoga or Resistance Exercise Training Fpr Parkinson's Patients

The investigators propose to compare the effects of a 16-week specially designed yoga program to a power-based resistance training program on affect trait mindfulness, anxiety, depression, functionality, and quality of life. As secondary me

Coral Gables, Florida, United States
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CompletedPhase 4

Solifenacin Succinate (VESIcare) for the Treatment of Overactive Bladder in Parkinson's Disease

This study will assess the effectiveness of solifenacin succinate (VESIcare) in reducing symptoms of overactive bladder in Parkinson's disease (PD) patients.

Miami, Florida, United States+2 more
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CompletedPhase 2

Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/Parkinsonism

This study is being conducted this study to determine whether injections of Xeomin®, a type of botulinum toxin into the glands that produce saliva (one pair just below and in front of the ear and the other just under the jaw line) are safe

Boston, Massachusetts, United States
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Unknown

Prospective Study to Compare Results of STN-DBS Between Early Treated and Late-treated PD Patient

The aim of this study is to investigate the impact of DBS not only no motor outcomes, but also on neuropsychological and psychiatric aspects and on quality of life in young patients with a short history of disease.

Bergamo, Lombardy, Italy
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Recruiting

LFP-based Parameter Prediction in DBS for Parkinson's Disease

The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. The main question it aims to answer is:

Leuven, Vlaams-Brabant, Belgium
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CompletedEARLY_Phase 1

Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the Brain

The overall goal of this protocol is to evaluate \[18F\]MNI-1216 (also known as \[18F\]ACI-12589) as an α-synuclein targeted radiopharmaceutical in 3 parts as follows: * Part 1: first in human (FiH) imaging * Optional Part 2: expansion of

New Haven, Connecticut, United States
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RecruitingN/A

Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome

This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome. Accelerated TIS will b

Guangzhou, Guangdong, China
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