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UnknownN/A

Effect of Physical Rehabilitation in Patients With Parkinson's Disease

This is a prospective study. The aim of this study is to investigate the effect of exercise retraining on cardiorespiratory parameters, postural balance, sociopsychological variables, and cognitive function in subjects with Parkinson's dise

Multiple locations
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RecruitingEARLY_Phase 1

Title: A Multimodal Exercise Program With Gamification for Parkinson Disease (MEP+G)

In this pilot study the research will explore whether exercises and the outcome measures would be acceptable to conduct a more detailed research study. This 8 week pilot study will utilize a comprehensive exercise program that includes non-

Ventura, California, United States
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TerminatedPhase 3

Study of the Efficacy of N-acetylcysteine (NAC) on Impulse Control Disorders

Impulse control disorders encountered in Parkinson's disease (PD) are induced by dopaminergic medications and their frequency is estimated to be nearly 20%, mainly under dopaminergic agonists (AD).

Amiens, Picardie, France
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Completed

Developing Personalized Medicine Strategies to Increase Physical Activity in Parkinson's Disease (PD) Through Digital Health Technology

Under a grant from the Department of Defense's PD program, Dr. Morley's is investigating new approaches that 1) use "gamification"- applying rules of games like point scoring, achieving silver, gold or platinum levels and competition-- to i

Philadelphia, Pennsylvania, United States
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Not yet recruiting

The Role of Priors in Hallucinatory Perception in Parkinson's Disease

The goal of this observational study is to better understand the mechanisms of hallucinations in patients with Parkinson's disease. The main question it aims to answer is: Do prior expectations increase the rate of false perceptions during

La Tronche, France
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CompletedN/A

Effects of Inspiratory Muscle Training in Patients With Parkinson's Disease

In this study investigators will examine the effects of inspiratory muscle training and balance training in patients with Parkinson's Disease

Istanbul, Turkey (Türkiye)
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CompletedN/A

Effects of Cycling Dual-task in Parkinson's Disease.

Taking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the evolution of the pathology, the objective of this study is to evaluate the effect of a dual-task program

Pontevedra, Spain
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CompletedPhase 1

To Assess the Effect of Administration of 2 Formulation of AZD3241 on Blood Concentration in Healthy Volunteers

To evaluate the pharmacokinetics of AZD3241 following multiple administration of 2 new, different extended release formulations of tablets of AZD3241 (300 mg), in relation to the 100 mg extended release tablet used in a previous study and p

London, United Kingdom
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Completed

Duodopa Home Titration Using Telemedicine: Evaluation of Use of Resources

The purpose of this study was to evaluate the use of resources during titration of Duodopa at home.

Multiple locations
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UnknownN/A

Action Observation Treatment in Parkinson's Patients

The aim of the study is to assess the role of Action Observation Treatment (AOT) and Motor Imagery (MI) in the rehabilitation of Parkinson's disease patients, as compared to a control condition. Main outcome measures will be the results in

Parma, Italy
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CompletedPhase 1

Effects of Virtual Reality Training in Patients With Parkinson's Disease

Background and Objective: Postural instability is common in patient with Parkinson's disease (PD). The purpose of this study was to investigate the effects of virtual reality (VR) balance training on sensory and cognitive domains of postura

Taipei, Taiwan
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CompletedN/A

Erythromycin in Parkinson's Disease

Gastroparesis (slow stomach emptying) is a common feature of Parkinson's Disease. Levodopa (Sinemet), a common medication for Parkinson's Disease, can make gastroparesis worse.

Richmond, Virginia, United States
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Completed

[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease

AIM: Investigate wether there are differences in the parasympathetic nervous system in Parkinsons patients compared to controls. MATERIALS AND METHODS: We use the tracer \[11C\]donepezil to image the parasympathetic nervous system.

Aarhus, Denmark
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CompletedPhase 1

Pharmacokinetic-Pharmacodynamic Interaction Between Four Different Single Doses of BIA 3-202 and a Single Dose of Levodopa/Carbidopa (100/25 mg)

The purpose of this study is to investigate the tolerability, pharmacokinetic profile of BIA 3-202 and its metabolites, and the pharmacokinetic and pharmacodynamic interaction between 4 different single doses of BIA 3-202 (50 mg, 100 mg, 20

S. Mamede Do Coronado, S. Mamede Do Coronado, Portugal
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TerminatedPhase 3

Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure

A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure

Sun City, Arizona, United States+81 more
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Unknown

Multi-disciplinary Rehabilitation Program for Advanced Parkinson's Patients in the Community

The present study examines the effectiveness of the rehabilitation program in the framework of the "Ezra LeMarpeh" project for Parkinson's patients. The Ezra LeMarpeh Association, founded by Rabbi A.

Tel Aviv, Israel+1 more
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Completed

Temporal Expectations in Parkinson's Disease

Although major progresses were realized during recent years, temporal cognition is still poorly understood. However, abnormal temporal cognition is an underestimated aspect of several neurological disorders, particularly if basal ganglia (B

Paris, France+1 more
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Active, not recruiting

Biomarkers in Parkinsonian Syndromes

This is a prospective observational study to identify biomarkers in parkinson syndromes. Patients with parkinsonian syndromes at the early stages of disease will be recruited and will be followed up until their established clinical diagnosi

Athens, Athens, Greece
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UnknownN/A

To Evaluate the Safety of DBS in Patients With Primary Parkinson's Disease

To evaluate the safety of implantable rechargeable computer deep nerve stimulation system produced by Jiangsu Changyida Medical Technology Co., Ltd. for patients with primary Parkinson's disease

Multiple locations
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Unknown

Asleep MRI-guided Versus Awake Microelectrode Recording Guided Deep Brain Stimulation in Parkinson's Disease: A Comparative Effectiveness Trial

Rationale: Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-accepted treatment for Parkinson's disease (PD). Traditionally, the procedure is performed awake and under local anaesthesia to facilitate intraope

Multiple locations
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