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CompletedPhase 3

A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease

The purpose of this study is to evaluate the efficacy of 40 mg a day of istradefylline (KW-6002) for reducing the percentage of awake time spent in the OFF state in patients with advanced Parkinson's disease treated with levodopa.

Slough, Berkshire, United Kingdom
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CompletedPhase 1 / Phase 2

Adipose-derived Stromal Vascular Fraction Cells to Treat Parkinson

This is an interventional study to treat 10 patients with a diagnosis of Parkinson's disease with neurological assessment from the Oxford Parkinson's Disease Quotient-39 (PDQ-39) and Movement Disorders Society Universal Parkinson's Disease

León, León Department, Nicaragua
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UnknownN/A

Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS

The objective is to investigate whether AMPS (Automated Mechanical Peripheral Stimulation) is effective in reduction of FOG measured via the FOG-AC (Freezing Of Gait Assessment Course) in people with Parkinson Disease and STN-DBS (Subthalam

Cologne, North Rhine-Westphalia, Germany
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Recruiting

Retinal Imaging in Neurodegenerative Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and

Durham, North Carolina, United States
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CompletedPhase 1

A Trial Investigating Lu AF28996 in Adult Japanese Participants With Parkinson's Disease (PD)

This trial will evaluate the effects of Lu AF28996 in adult Japanese men and women with Parkinson's disease (PD). The main goals of the trial are to learn more about a) the safety and tolerability of Lu AF28996 (any new or worsening medical

Ehime, Japan
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CompletedN/A

Blood Flow Restriction and Exercise in Parkinson's Disease

The goal of this clinical trial is to learn whether training with blood flow restriction (BFR), combined with aerobic exercise (performing stepping on a Nu-Step exercise machine), can help improve mobility and other outcomes in people with

San Francisco, California, United States
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TerminatedPhase 4

Anxiety in Parkinson's: Use of Quantitative Methods to Guide Rational Treatment

This study will evaluate the effectiveness of the rotigotine transdermal patch in reducing anxiety in people with Parkinson's disease.

Baltimore, Maryland, United States
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CompletedN/A

The Effectiveness of LSVT-BIG Training in Improving Balance and Gait in Parkinson's Patients

Parkinson's disease (PD) is a chronic, progressive disease that causes motor and non-motor symptoms due to dopaminergic neuron loss. Today, the treatment of PD in addition to optimal medical and surgical treatments, physiotherapy and rehabi

Ankara, Turkey (Türkiye)
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Active, not recruitingPhase 2

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

This is a multicenter, randomized, double-blind, placebo-controlled study that will evaluate the efficacy and safety of intravenous (IV) prasinezumab versus placebo in participants with Early Parkinson's Disease (PD) who are on stable sympt

Birmingham, Alabama, United States+109 more
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Recruiting

Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene

This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene. The study compares these patients to indiv

Brindisi, Italy+3 more
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CompletedPhase 2

Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients

The purpose of this study is to determine whether Green Tea Polyphenol, an extraction from Green Tea is effective and safe in the treatment of De Novo Parkinson's disease Patients without taking any antiparkinsonism drug

Beijing, China
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Completed

Aquaporin-4 Single Nucleotide Polymorphisms in Patients With Idiopathic and Familial Parkinson's Disease

The purpose of this study is to understand the relationship between problems in sleep, genetic variations in the Aquaporin-4 gene (AQP4), and the development of Parkinson's Disease.

Ashford, United Kingdom+3 more
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Completed

Evaluation of Anticholinergic Load

Drugs with anticholinergic properties may cause central and peripheral side effects. Several scales have been developed to evaluate the anticholinergic effect of drugs.

Montpellier, France
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WithdrawnPhase 2

BIIB014 Phase 2a Monotherapy

To assess the preliminary safety and tolerability of multiple oral doses of BIIB014 in subjects with early PD.

Multiple locations
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CompletedN/A

Exercise for Cognitive Excellence in Parkinson's Disease

This study will evaluate the safety and feasibility of a home-based, virtually-supervised, combined high intensity endurance and resistance training program in people with Parkinson's disease. It will also evaluate the effects of exercise o

San Francisco, California, United States
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CompletedN/A

Stress-Busting Program for Caregivers of Patients With Neruological Diseases

Although family caregivers perform an incredibly valuable service for their relatives and the formal health care system, they do so at a considerable cost to themselves both emotionally and physically. Effective stress management techniques

San Antonio, Texas, United States
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Active, not recruitingN/A

Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease

This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application sites. Each

A Coruña, Spain
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Completed

Walking and Thinking - Brain Activity During Complex Walking in Aging and Parkinson's Disease

Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as Parkinson

Stockholm, Solna, Sweden
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CompletedN/A

Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation

The implementation of virtual reality (VR) and robotic devices in neuromotor rehabilitation has so far provided promising evidence in terms of efficacy throughout different clinical populations. Positive changes in patient's motor and funct

Pavia, PV, Italy
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CompletedPhase 1

Safety of CERE-120 (AAV2-NTN) in Subjects With Idiopathic Parkinson's Disease

This is a Phase I dose escalating open-label study designed to assess the safety, tolerability and biologic activity of an in vivo AAV2 mediated delivery of the gene encoding NTN (CERE-120). Twelve (up to 18) subjects will receive one of tw

San Francisco, California, United States+1 more
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