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CompletedN/A

COPE-Co-morbidities, Parkinson's Disease and Exercise

Problems with balance and walking that affect mobility are an inevitable cause of decreased quality of life in older people with chronic neurologic conditions such as Parkinson's disease (PD). Although there is evidence that exercise can im

Portland, Oregon, United States
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CompletedN/A

Analgesic Effects of Expectation and Deep Brain Stimulation in Patients With Parkinson's Disease

The study investigates analgesic effects of expectations and deep brain stimulation on chronic and evoked pain in patients with Parkinson's disease. The study includes patients with Parkinson's disease that are exposed to pain stimuli throu

Aarhus, Denmark
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Unknown

Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease

The project intends to assess the polygenic burden of rare disruptive mutations in Parkinson's disease (PD) and how they influence the phenotype/pathological heterogeneity of disease.

Pozzilli, Italy
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CompletedN/A

Effects of Motor Imagery and Action Observation on Upper Limb Motor Chances and Cognitive Chances in Parkinson's Disease

Parkinson's disease is degenerative, progressive, and chronic. It is considered potentially disabling, in view of the motor alterations, such as bradykinesia, rigidity, and tremor in the upper limbs, and non-motor alterations, such as cogni

Porto Alegre, Brazil
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Completed

Predicting Motor Learning of an Upper Limb Task Based on Behavioral and Disease-specific Characteristics in Patients With Parkinson's Disease

Manual dexterity deficits and loss of motor automaticity are commonly seen in patients with Parkinson's disease (PD). Amongst these problems, using a touchscreen is becoming increasingly burdensome.

Leuven, Belgium
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Not yet recruitingN/A

VC/VS for Apathy in PD

Apathy is a disabling neuropsychiatric symptom marked by reduced goal-directed behavior, including diminished interest, motivation, emotional expression, and social engagement. Though not formally defined in the DSM-V, apathy is common in s

Houston, Texas, United States
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Completed

Evaluation of a Biomarker Related to the GI Tract for the Diagnosis of Parkinson's Disease

The cause of Parkinson's disease (PD) is currently unknown. Both environmental and genetic factors have been found to contribute to PD pathogenesis.

Chicago, Illinois, United States
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Unknown

Identifying New Biomarkers of Parkinson's From Routine Brain Imaging

The study will use routine computer tomography (CT), magnetic resonance spectroscopy (MRI) and nuclear medicine (NM) brain imaging data to produce new diagnostic tests for the onset of Parkinson's disease. This will enable hopefully earlier

Multiple locations
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Completed

A Survey Study to See if Patients Diagnosed With Parkinson's Disease Have Higher Incidence of Melanoma

Patients with Parkinson's disease will be seen by a dermatologist who will biopsy any suspicious skin lesions.

Multiple locations
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CompletedN/A

Evaluating the Influence of Externally vs. Internally Focused Exercise on Rehabilitation in Parkinson's Disease

The purpose of this study is to evaluate the underlying mechanism and influence of externally vs. internally focused exercise on rehabilitation in Parkinson's disease.

Multiple locations
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Unknown

Comparison of the Incidence of Dyskinesia in Parkinson's Disease Who Were Treated With Amantadine or Dopamine Agonist

The purpose of this study is to compare the onset time and severity of dyskinesia in amantadine or Dopamine agonist initial treated groups in Parkinson's disease.

Seoul, South Korea
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UnknownN/A

Is Remote Physiotherapy Effective for People With Early Parkinson's (PEEP)

Parkinson's disease is a progressive neurodegenerative condition affecting 145,500 people in the UK. The condition impairs movement leading to gait and dexterity problems.

Multiple locations
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CompletedEARLY_Phase 1

Improving Walking Automaticity in Parkinson's Disease: Levodopa or Donepezil

Safe and independent mobility at home and in the community requires control of walking while accomplishing other functional tasks. A hallmark of healthy control of walking is automaticity, defined as the ability of the nervous system to suc

Portland, Oregon, United States
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Completed

Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease

In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. The investigators recent

Boston, Massachusetts, United States+3 more
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CompletedN/A

Mild Cognitive Impairment and Endurance Exercise in Parkinson's Disease

The overall objective of this study is to determine how high intensity endurance exercise affects both cognition and the signs and symptoms of Parkinson's disease as well as if certain brain structures and functions also change with this ex

Chicago, Illinois, United States
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UnknownPhase 2

Fipamezole in Neurogenic Orthostatic Hypotension

The purpose of this study is to determine whether Fipamezole is effective in the treatment of orthostatic hypotension and related symptoms in multiple system atrophy and Parkinson's disease.

Bordeaux, France+3 more
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CompletedN/A

Using Low Intensity Focused Ultrasound to Modulate Deep Brain Areas for Tremor Control in Parkinson's Disease Patients.

Researchers have found that a treatment called Magnetic Resonance guided Focused Ultrasound (MRgFUS) can effectively reduce tremors in patients with essential tremor (ET) and Parkinson's disease (PD). They noticed that ET patients initially

Vancouver, British Columbia, Canada
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UnknownN/A

Parkinson's Disease and Gamma-transcranial Alternating Current Stimulation

Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinson's disease (PD) and the plasticity of the primary motor cortex (M1) is impaired. Enhancing gamma oscillations through transcranial alternating current stimulat

Pozzilli, Italy
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Recruiting

Respiratory Functions in Parkinson's Disease

The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients. Individuals between the ages of 50-80 who have been diagnosed with Parkin

Ankara, Turkey (Türkiye)
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CompletedN/A

Prism Adaptation Treatment of Parkinson's Disease

Subjects diagnosed with Idiopathic Parkinson's Disease, between ages of 40-85 inclusive, who have been referred for gait training. Since there can be subtle differences in the brain organization of left- and right-handed people that may inf

Lebanon, New Hampshire, United States
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