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UnknownN/A

Monitoring Brain Waves in Response to Visual and/or Auditory Stimulation in Parkinson's Disease Patients

Voltage fluctuation as a result of brain activity will be recorded into the computer using an EEG device.

Multiple locations
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Not yet recruitingPhase 2

Methylphenidate for Apathy in Veterans With Parkinson's Disease

Apathy is one of the most common behavioral symptoms of Parkinson's disease. Patients with apathy show diminution in motivation and goal-directed behaviors, which is a fundamental aspect of human functioning, affecting dependency and qualit

Multiple locations
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RecruitingPhase 1 / Phase 2

Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

This is a Phase 1/2 study to evaluate the safety and tolerability of 18F-OP-801 in subjects with ALS, AD, MS, PD and age-matched HVs. 18F-OP-801 is intended as a biomarker for PET imaging of activated microglia and macrophages in regions of

San Francisco, California, United States+2 more
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CompletedPhase 1

Repurposing Lithium for Parkinson's Disease

This study will examine the effects of lithium aspartate 30-45mg/day on MRI biomarkers and blood-based therapeutic targets among 15 early-stage Parkinson's disease patients.

Williamsville, New York, United States
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CompletedN/A

Psychoeducational Programme for PD Patients With STN-DBS

Bilateral subthalamic deep-brain stimulation is a well-established therapeutic option to improve motor signs and reduce dopaminergic treatment and related motor complications in patients with severe forms of Parkinson's disease (PD). Howeve

Paris, Paris, France
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CompletedPhase 1 / Phase 2

Effects of Talampanel on Patients With Advanced Parkinson's Disease

The purpose of this research study is to test the safety and effectiveness of the study drug, Talampanel, when used to treat patients with involuntary movements known as dyskinesias, as a result of treatment to Parkinson's disease. It is no

Multiple locations
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TerminatedPhase 2

Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease

The purpose of this study is to determine the safety and efficacy of AAV-GAD gene transfer into the subthalamic nucleus (STN) region of the brain. This study involves the treatment of subjects with medically refractory Parkinson's disease (

Stanford, California, United States+6 more
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UnknownN/A

PaDAWAn: Parkinson's Disease - Adaptive Walking Assistance

The goal of this study is to develop and validate a haptic assistive method in order to support walking in patients with Parkinson's disease, delivered to the patient's hips through a wearable robotic pelvis orthosis.

Brussels, Belgium
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Completed

Nocturnal Parkinson's Disease Symptoms Study Group

To study associate factor of Noctural Parkinson's Disease Symptoms and quality of life in Parkinson's disease patients and caregivers.

Pathumwan, Bangkok, Thailand
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CompletedPhase 2

Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)

This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD).

Birmingham, Alabama, United States+22 more
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CompletedN/A

Subthalamic Nucleus (STN)-Targeted Transcranial Temporal Interference Stimulation (TIS) for Parkinson's Disease: Efficacy and Safety From a Single-Center, Prospective, Double-Blind Randomized Controlled Trial

This is a single-center, prospective, double-blind, randomized controlled trial to evaluate the efficacy and safety of transcranial temporal interference stimulation targeting the subthalamic nucleus in patients with Parkinson's disease. It

Wuhan, Hubei, China
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Completed

Change in Gastrointestinal Complaints After Switch From Oral Parkinson's Disease Treatment to Neupro® Transdermal Patch

The study intends to collect data on gastrointestinal symptoms (swallowing disorders, heartburn, feeling of fullness, nausea, vomiting, abdominal pain, diarrhea) and on patient satisfaction under everyday practice conditions after changing

Berlin, Germany+20 more
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CompletedPhase 3

Study of Azilect® (Rasagiline) in Levodopa-treated Parkinson's Disease Patients With Motor Fluctuations in Korea

To evaluate the efficacy of a fixed dose of Azilect® (1 mg/day) vs placebo as assessed by the change from baseline in mean total daily OFF time during 18 weeks of treatment in levodopa-treated Parkinson's Disease (PD) patients with motor fl

Multiple locations
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CompletedPhase 3

Nicergoline Use in Dysphagia Patients

Dysphagia is a complication in patient with stroke, Parkinson's disease or dementia that can lead to aspiration pneumonia. This study aimed to investigate dysphagia improvement after treatment with nicergoline low dose and high dose, the re

Ratchathewi, Bangkok, Thailand
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CompletedN/A

Stochastic Resonance Stimulation Effect on Gait Stability in Parkinson Disease

The present study explored the use of a technique called stochastic resonance (SR) stimulation that may help individuals with Parkinson Disease maintain balance while walking on challenging surfaces. Impaired balance represents one of the d

Newark, Delaware, United States
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Suspended

Clinical Characteristics of Parkinson's Disease Subjects With Severe Hypertension During Motor OFFs.

Current management of hypertension in PD motor fluctuators is flawed. The current practice often is to treat transient hypertensive spikes reported by patients or measured in clinics with anti-hypertensive medications.

Portland, Oregon, United States
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TerminatedPhase 1

Safety Evaluation of Intravenous Talineuren (TLN) in Parkinson's Disease-affected Patients

This study is an open-label, single ascending dose escalation followed by a multiple administration dose at the maximal suitable dose (MSD). The investigational Medicinal Product (IMP) is given as an add-on therapy.

Konolfingen, Canton of Bern, Switzerland
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Unknown

Drug Discovery for Parkinson's With Mutations in the GBA Gene

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate Parkinson's disease research and drug development by using cells from the body (such as skin or blood cells) to make stem cells and other

New York, New York, United States
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CompletedN/A

Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor

This is a 6-week exploratory clinical study, designed to test whether treatment with peroneal electrical trans-cutaneous stimulation can have a beneficial effects on symptoms associated with Parkinson's diseases and essential tremor.

Ostrava, Czechia
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WithdrawnN/A

The Safety of Remote DBS Programming System

Remote programming has significant advantages over conventional programming methods on some issues. This research will test the safety of SceneRay remote and wireless DBS programming system.

Shanghai, Shanghai Municipality, China
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