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CompletedN/A

The Effect of Ischemic Training on Exercise Endurance

The purpose of this study is to determine if reducing blood flow to an exercising muscle during exercise training will enhance the training effect on that muscle in people who have limited exercise because of congestive heart failure

Albuquerque, New Mexico, United States
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UnknownPhase 1 / Phase 2

Treating Heart Failure With hiPSC-CMs

Heart failure has a high morbidity and mortality because the heart is one of the least regenerative organs in the human body. Drug treatments for heart failure manage symptoms but do not restore lost myocytes.

Shanghai, Shanghai Municipality, China
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Unknown

Palliative Outcome Evaluation Muenster I

For patients with an advanced disease and their families an excellent and compassionate care is essential. However, in hospitals optimal end-of-life care is not yet fully realized and patient's needs are often not met.

Münster, North Rhine-Westphalia, Germany+4 more
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UnknownPhase 1 / Phase 2

Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research

While trastuzumab has been shown to prevent recurrences of breast cancer, some women may also experience damage to their heart muscle (including heart failure) as a result of their treatment. The investigators hope to learn if standard medi

Edmonton, Alberta, Canada
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CompletedN/A

Improving Quality of Life in Heart Failure

This research study has been designed to test the efficacy of telephone-delivered Problem-Solving Treatment (PST) for improving the quality of life (QoL) in outpatients with stable heart failure (HF).

Denver, Colorado, United States
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Unknown

Efficacy and Safety of Finerenone in Heart Failure With Reduced Ejection Fraction

Finerenone is a new selective nonsteroidal mineral corticoid receptor antagonist (MRA), nowadays it's widely used in type 2 diabetes (T2DM) patients with chronic kidney disease (CKD), the newest trial shows finerenone improve the cardiovasc

Multiple locations
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RecruitingPhase 2

the Clinical Outcome of Empagliflozin in Pediatric Heart Failure Patients

the study to investigate the efficacy of empagiflozin in pediatric heart failure

Cairo, Cairo Governorate, Egypt
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UnknownN/A

Quantifying Congestion by Ultrasound

The investigators will determine the feasibility of identifying and quantifying changes in interstitial and intravascular congestion by imaging in participants with heart failure. The investigators will either continue or temporarily suspen

Glasgow, United Kingdom
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CompletedPhase 1

A Study of HRS-9057 in Patients With Heart Failure and Volume Overload

The study is an open-label, Tolvaptan-controlled Phase I study to evaluate the safety, tolerability, PK/PD profile and efficacy of HRS-9057 in the treatment of heart failure with volume overload. A total of 24 subjects who experience volume

Guangzhou, Guangdong, China
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CompletedN/A

Haiti Community Health Workers (CHW) Adaptation

Evidence-based interventions to improve linkage and outcomes for heart failure (HF) patients requires input from stakeholders: patients, community health workers (CHWs), healthcare staff, and health system administrators. In this research t

Mirebalais, Haiti
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Completed

Ventricular-Vascular Coupling in Heart Failure

This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e. normal left v

Boston, Massachusetts, United States
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By invitationPhase 2

Ketones in Heart Failure With Reduced Ejection Fraction

The purpose of this study is to understand the effects of a ketone drink on exercise capacity and other cardiovascular parameters in patients with heart failure. In heart failure, patients are limited in their ability to do all the things t

Durham, North Carolina, United States
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CompletedN/A

Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure

Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1). This finding is usually explained by alveolar tidal overdistension associated

Brescia, Italy
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Not yet recruitingN/A

RDN for Heart Failure

This is a single-center, prospective, single-arm clinical trial to evaluate the efficacy and safety of renal denervation (RDN) using a multi-channel radiofrequency ablation system in patients with symptomatic heart failure, including both h

Shanghai, Shanghai Municipality, China
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Unknown

Cardiovascular Imaging and Biomarker Analyses (CIBER)

"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is

Mannheim, Germany
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CompletedPhase 2

Evaluation of Patiromer in Heart Failure Patients

The purpose of this study was to assess the effects of patiromer on serum potassium participants with heart failure. This study also assessed the safety and tolerability of patiromer in participants with heart failure.

Miami, Florida, United States+32 more
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CompletedN/A

Heart Failure Resilience Intervention for Caregivers

Heart failure (HF) patients with supportive caregivers have better physical health, emotional health, and quality of life. But caregivers have an increased risk of caregivers' own worsening health and often feel a sense of burden related to

Baltimore, Maryland, United States
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CompletedN/A

Proof-of-Concept Study of Heart Habits Application for Patients With Heart Failure

This study assesses the ability of ambulatory patients with heart failure (HF) to use a smartphone application created for the management of patients with chronic HF. This study will aim: * To understand the frequency with which ambulatory

Boston, Massachusetts, United States
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CompletedN/A

CCM in Heart Failure With Preserved Ejection Fraction

This pilot study will evaluate the efficacy and safety of CCM therapy in heart failure patients with baseline EF≥50% (HFpEF) who have New York Heart Association (NYHA) Class II or III symptoms despite appropriate medication. The terminology

Bundaberg, Queensland, Australia+16 more
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CompletedPhase 3

Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure

The purpose of this study is to compare high dose furosemide in combination with low volume hypertonic saline solution (2.4%) with intermittent pulse dose furosemide in patients with pre treatment kidney function impairment. The hypothesis

Wausau, Wisconsin, United States
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