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Recruiting

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital a

Boston, Massachusetts, United States+2 more
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RecruitingPhase 4

A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record

The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure. Patients who are prescribed either empagliflozin or dap

Copenhagen, Denmark+11 more
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Active, not recruiting

The Jackson Heart Study of Cardiovascular Disease Among African Americans

This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults. The cohort is a collaboration among multiple institutions (Jackson State Univers

Jackson, Mississippi, United States
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CompletedPhase 2

Heart Failure and Anemia

The purpose of this study is to determine whether increasing hemoglobin concentration in patients with heart failure and anemia will improve the patients' functional status, including exercise tolerance and New York Heart Association (NYHA)

Multiple locations
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RecruitingN/A

Ketogenic Diet vs Mixed Diet in Patients With Heart Failure

This study is being done to evaluate the effects of a low carbohydrate ketogenic diet (KD) versus a low-fat diet (MD) on exercise tolerance in participants with heart failure with normal pumping function and diabetes or pre-diabetes, or met

Columbus, Ohio, United States
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SuspendedPhase 4

The Effects of Dobutamine on Postoperative Cardiac Function in Aortic Valve Replacement

The use of dobutamine in postoperative hemodynamic treatment is widespread despite seemingly intact contraction of the heart. This study aims to elucidate the efficacy of low-dose dobutamine infusion in patients in the postoperative phase r

Aarhus, Denmark
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Completed

Adherence of Diuretics in Pulmonary Hypertension

In this prospective study, the investigators will implement a systematic assessment of adherence to diuretics in a cohort of patients with precapillary pulmonary hypertension. This study is designed to: * determine the overall adherence ra

Le Kremlin-Bicêtre, France
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CompletedN/A

Efficacy and Cost Effectiveness of Relaxation and Response to CHF

Despite the development of significant pharmaceutical treatments, morbidity and mortality of chronic heart failure (CHF) patients remain high, patients� quality of life is poor, and their health care utilization is heavy. It is therefore im

Bedford, Massachusetts, United States
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WithdrawnEARLY_Phase 1

Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults

Evaluate the feasibility of administering plasma (PF24) acquired from donors of a young chronological age intravenously to older adults at WFBMC while also exploring its effects on age-related functional decline

Winston-Salem, North Carolina, United States
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TerminatedPhase 2

QUantum Genomics Incremental Dosing in Heart Failure - QUID-HF

Heart Failure (HF) a common clinical condition characterized by either by a heart that does not pump sufficiently or becomes stiff. A variety of mechanisms contribute to progressive cardiac remodeling and dysfunction.

Frýdek-Místek, Czechia+22 more
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CompletedPhase 3

Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)

Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduced blood flow throughout the body, congestion of blood in the veins and lungs, and fluid accumulation i

Atlanta, Georgia, United States+8 more
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WithdrawnN/A

Ultrasound-guided Treatment in Acute Heart Failure

A randomized non-blinded study comparing ultrasound-guided therapy with conventional therapy in acute heart failure patients.

Multiple locations
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CompletedPhase 2

VitamIN D Treating patIents With Chronic heArT failurE

Despite recent advances and even when receiving optimal therapy, patients with chronic heart failure (CHF) suffer poor quality of life, with recurrent hospitalisations and persistent symptoms. The investigators have shown that patients atte

Leeds, United Kingdom
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CompletedN/A

Effect of Short-term Oxygen During CPET in HFpEF

In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart fai

Zurich, Switzerland
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CompletedPhase 4

Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism

Currently there is no clear guidance for the treatment of moderate risk of pulmonary embolism. The aim of the study is to compare two different therapeutic modalities - standard anticoagulation versus thrombolytic treatment followed by anti

Opava, Czechia+1 more
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WithdrawnN/A

Health Behavior-Related Outcomes With Diaphragmatic Breathing Retraining in Heart Failure Patients

The purpose of this study is to provide information on how the practicing of deep breathing ("DBR" - diaphragmatic breathing re-training) may improve the health outcomes and likelihood of heart failure patients to engage in health-promoting

Multiple locations
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UnknownPhase 2

Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure: APIXBRAIN-HF Trial

objectives: The primary aim of APIXBRAIN-HF Trial is to explore the effects of apixaban on brain protection in patients with sinus rhythm and heart failure Primary / Secondary Endpoint 1. New occurrence of brain pathology 1) Cortical cere

Seoul, Guro-gu, South Korea+9 more
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Completed

RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.

Postoperative acute renal failure is a frequent complication after cardiac surgery. The current practice cannot predict Acute Kidney Injuries (AKI) early enough to reduce a significant kidney assault and prevent an organic dysfunction leadi

Pessac, Bordeaux, France
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UnknownN/A

The Comparison With Clinical Impacts on Functional Capacity and Symptom Improvement According to the Rhythm Control in Patients With Heart Failure and Recent Onset Atrial Fibrillation

Prospective randomized (rhythm control or rate control in heart failure patients with new onset atrial fibrillation) Objective of study 1. To analyze long term outcome of patients with heart failure with new onset atrial fibrillation accord

Seoul, South Korea
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Completed

Predicting Heart Failure Outcomes With Biomarkers and Imaging

This study aims to develop a better model to predict one-year risk of death in patients with heart failure. We will test whether combining information from routine blood tests (like NT-proBNP) and heart scans (measuring features like epicar

Multiple locations
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