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UnknownN/A

Resistance Training in Cardiovascular Disease Patients

In this study coronary artery disease patients and patients with heart failure will be randomly assigned to three training groups: combined aerobic interval training with high intensity resistance training, combined aerobic interval trainin

Murska Sobota, Slovenia
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Not yet recruitingPhase 4

Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients

The TARGET trial is a prospective, single-center, randomized, open-label, active-controlled inequality clinical trial designed to evaluate the safety and efficacy of low-intensity anticoagulation therapy (target INR 1.5-2.0) compared to sta

Seoul, South Korea
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CompletedPhase 4

VAccination to Improve Clinical outComes in Heart Failure Trial: a Feasibility Study (VACC-HeFT)

A multi-center, prospective, randomized, open-label blinded-endpoint trial in patients with heart failure will be conducted; 20 will be assigned to the standard dose vaccine dose and 20 patients to high dose influenza vaccine. Post-vaccine

Madison, Wisconsin, United States
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WithdrawnN/A

The Role of Adrenomedullin on the Outcome of Severe Heart Failure: a Clinical Randomized Study

1. Study Hypothesis: * The decrease of plasma adrenomedullin (ADM) concentration by ultrafiltration and isovolumetric hemofiltration in patients with acute III and IV Class New York Heart Association Functional(NYHA) heart failure is mo

Porto Alegre, Rio Grande do Sul, Brazil
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CompletedPhase 3

BAMI. The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells(BM-MNC) on All Cause Mortality in Acute Myocardial Infarction

This is a multinational, multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a single intracoronary infusion of autologous bone marrow-derived mononuclear cells is safe and reduces

Aalst, Belgium+32 more
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Active, not recruiting

Symptom Burden and Health Related Quality of Life of Cancer Patients With Concurrent Heart Failure

To describe and compare the symptom burden in cancer patients with concurrent diagnosis of heart failure (HFrEF compared to HFpEF).

Houston, Texas, United States
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RecruitingPhase 3

Qishen Yiqi Dripping Pills in Treatment of Chronic Heart FailUre

This trial will evaluate the efficacy and safety of Qishen Yiqi Dripping Pills in treatment of Chronic Heart Failure with reduced ejection fraction resorted from Coronary Heart Disease (Syndrome of Qi Deficiency with Blood Stasis).

Bozhou, Anhui, China+59 more
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CompletedN/A

Virtual Care to Improve Heart Failure Outcomes (VITAL-HF)

The purpose of this study is to evaluate how safe and effective a remote, digital intervention is that helps clinicians use and optimally adjust heart failure medications, compared to usual care medication use and adjustment, in participant

Panama City, Florida, United States+6 more
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CompletedN/A

Evaluating the Adherence Improving Self-Management Strategy Intervention in Chronic Heart Failure Patients

Patient non-adherence to treatment recommendations is common and decreases the effectiveness of Chronic Heart Failure (CHF) treatment. Improving adherence towards medication intake, physical activity, symptom monitoring/management might pro

Nijmegen, Gelderland, Netherlands+2 more
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UnknownPhase 2 / Phase 3

Stellate Ganglion Block as Novel Treatment for Heart Failure Patients

Stellate Ganglion Block as Novel Treatment for Heart Failure Patients

Asyut, Egypt+1 more
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UnknownN/A

The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia

The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia. The hypothesis is that strict fluid re

Copenhagen, Denmark+1 more
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Recruiting

Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology

This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with reduced ejecti

Seoul, South Korea
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CompletedPhase 3

Triple Site Ventricular Stimulation for Cardiac Resynchronization Therapy (CRT) Candidates

Despite technological progresses the rate of non-responders to cardiac resynchronization therapy (CRT) remains close to 30%. This inconsistent effect of CRT might be due to incomplete resynchronization as dyssynchrony can persist in 25% to

Bordeaux, France+11 more
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UnknownPhase 4

Ventricular Pacing Site Selection (V-PASS)

The purpose of this study is to determine whether there is a relationship between ventricular lead position and the incidence of heart failure and atrial fibrillation in patients with indication for permanent pacemaker stimulation.

Bad Krozingen, Germany+2 more
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TerminatedPhase 3

Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

This was a multicenter, randomized (1:1; oral treprostinil to placebo), double-blind, placebo-controlled study in subjects with World Health Organization (WHO) Group 2 pulmonary hypertension (PH) associated with heart failure with preserved

Birmingham, Alabama, United States+81 more
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RecruitingPhase 3

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Combination therapy of finerenone plus empagliflozin will be compared to usual care to determine the efficacy and safety of treatment in patients hospitalized with heart failure.

Fairhope, Alabama, United States+103 more
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Not yet recruiting

Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions: the OROBICA Registry.

The OROBICA (Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions) Registry is a multicenter, ambispective, real-world observational study designed to evaluate clinical, procedural, imaging, and e

Bergamo, Bergamo, Italy
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UnknownPhase 1

Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)

To determine the safety profile of CAP-1002 administered by multi-vessel intracoronary infusion in subjects with DCM. The study will further explore safety and exploratory efficacy endpoints of CAP-1002.

Los Angeles, California, United States
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UnknownPhase 3

Ivabradine Effects in Cardiogenic Shock Requiring Inotropic Support

Data regarding the safety and efficacy of ivabradine use in severely decompensated HFrEF requiring inotropic support is limited to case series.1 This study aimed to evaluate ivabradine safety and tolerability in admitted cardiogenic shock p

Alexandria, Egypt+1 more
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RecruitingN/A

Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure

The goal of this clinical trial is to evaluate two treatment strategies in patients with chronic atrial fibrillation and heart failure, who are eligible for atrial fibrillation ablation. Patients will be randomized to either atrial fibrilla

Graz, Austria+17 more
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