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CompletedN/A

rTMS and Cognitive Training in Youth Depression

Youth depression is a highly prevalent disorder with tremendous personal and societal costs. Guideline supported treatments are limited in efficacy and associated with side effects.

Toronto, Ontario, Canada
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CompletedPhase 2 / Phase 3

Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression

Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may exert larger effects.

Tübingen, Germany
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Not yet recruitingN/A

A Study of a Mental Fitness Intervention for Anesthesiology Resident Wellbeing and Self-Compassion

The goal of this clinical trial is to learn if app-based wellness programs can help improve wellbeing and self-compassion for medical residents. This is a pilot study, which is done on a small group of people to learn if a larger study woul

Boston, Massachusetts, United States+1 more
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WithdrawnPhase 2 / Phase 3

Neural and Antidepressant Effects of Propofol (Phase 2)

Moderate-intensity propofol treatments will be administered to participants who are non-responders at the end of Phase 1.

Salt Lake City, Utah, United States
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CompletedPhase 4

Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression

The primary objective of the study is to evaluate whether armodafinil at a target dosage of 200 mg/day is more effective than placebo treatment in improving excessive sleepiness in patients with obstructive sleep apnea/hypopnea syndrome (OS

Jasper, Alabama, United States+61 more
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CompletedPhase 3

Risperidone and Suicidality in Major Depressive Disorder

The purpose of this trial is to investigate the efficacy of risperidone as an adjunct to an antidepressant treatment in the acute management of suicidality during an episode of major depressive disorder.

Birmingham, Alabama, United States
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RecruitingN/A

Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression

In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based on individual resting state connectivity improves treatment outcomes in major depressive disorder (MDD). For the trial,

Ottawa, Ontario, Canada
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CompletedN/A

Treatment Choices for Improving Adherence and Outcome

This study will determine the effectiveness of offering primary care patients their preferred treatment versus one that is less desirable in improving treatment adherence and outcome.

New York, New York, United States+1 more
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WithdrawnPhase 4

Preoperative Ketamine and Perioperative Depression

Depressive symptoms, in patients with a life history of major depressive disorder (MDD), are very common in the general population, and are especially so in elderly adults undergoing surgery.Symptoms of depression at the time of surgery is

Multiple locations
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Terminated

Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients

The main objective of this study is to confirm the existence of risky decision making in a non strategic situation (Iowa Gambling Task) and a deficit of decision making in social situations, linked to greater sensitivity to injustice (Ultim

Nîmes, France+1 more
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RecruitingN/A

Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

This study will identify unique signatures that people have which can cause pain by evaluating biological, psychological, and social markers using artificial intelligence. These markers can be used to accurately predict the response of dive

Boston, Massachusetts, United States
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UnknownN/A

Safety and Efficacy Study of Deep Transcranial Magnetic Stimulation in Bipolar Depression

The purpose of the study is to evaluate the efficacy and safety of H1-Coil deep brain rTMS in subjects with bipolar depression, taking mood stabilizers and previously unsuccessfully treated with antidepressant medications.

Juno Beach, Florida, United States+12 more
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CompletedN/A

Using Peer Mentors to Deliver Depression Care

Can peer mentors be integrated into depression care to older adults with mental health professional supervision? We will assess whether peer mentors who are lay persons who are in recovery from depression can provide depression care service

Baltimore, Maryland, United States
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Not yet recruitingN/A

The Effect of Cold Packs on Hot Flushes and Depression in Women Going Through the Climacteric Period

This study is planned as a pre-post test, randomised controlled, experimental trial designed to determine the effect of applying a cold gel pack to the Sanyinjiao (SP6) and Hegu (Large Intestinal 4 (LI4)) acupoints on hot flushes and depres

Ankara, Turkey (Türkiye)
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Active, not recruitingN/A

Neuromodulation of Mind-Wandering in Depression

The specific aim of this proposed study is to investigate the feasibility and therapeutic potential of LIFUP in changing negative cognition in depression. Specifically, the investigators will study if modulating DMN activity can change mala

Boston, Massachusetts, United States
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UnknownN/A

Efficacy of Guided and Unguided Online Self-help Psychological Intervention

This study will examine the efficacy of guided and unguided online transdiagnostic self-help cognitive behavioral therapy (CBT) for reducing anxiety and/or depression symptoms in Hong-kong residents. Numerous literature demonstrates online

Shatin, Hong Kong
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CompletedN/A

Exploratory Trial of a Group Psychological Intervention for Postnatal Depression in British Mother's of South Asian Origin

This study is an exploratory randomized controlled trial (RCT) of a group psychological intervention for postnatal depression in British mother's of south Asian origin. The aim is to evaluate the efficacy of a group psychological interventi

Borough of Blackburn With Darwen; Burnley; Preston; Manchester, Lancashire, Greater Manchester, United Kingdom
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CompletedN/A

Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing Home

The current use of telepsychiatry, or psychiatric care using videoconferencing, is very limited. The present study investigates the use of this method with a depressed Chinese American population in a nursing home.

Boston, Massachusetts, United States+1 more
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RecruitingPhase 2

Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. The purpose of this study is to assess the fe

Toronto, Ontario, Canada
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CompletedPhase 2

SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms. The purpose of this study is to help answer the fo

Little Rock, Arkansas, United States+81 more
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