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CompletedN/A

What SSI Duration is Most Effective? An Online Experiment With American Adults

In a previous study (https://osf.io/qdznc), the research team found that an 8-minute version of a single-session intervention for loneliness was more effective than a 23-minute version of it. The present work aims to further explore the rel

Chicago, Illinois, United States
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Not yet recruitingN/A

Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment

The main objective of the current research project is to evaluate the usability, satisfaction of the antenatal iCBT program including telephone coaching for antenatal and postnatal depressive symptoms and collect nationally representative d

Turku, Finland
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By invitation

Psychopathology in Adolescence

This observational study aims to evaluate the effectiveness of two different psychotherapy approaches-Cognitive Behavioral Therapy (CBT) and Brief Strategic Therapy (BST)-in treating adolescents with psychological disorders. The study will

Messina, Italy, Italy
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CompletedN/A

Moving on After Breast Cancer Plus- for Breast Cancer Survivors

Breast cancer (BC) ranks second among all the types of cancer and is equally common in developing as well as developed countries. Breast cancer is most common type of cancer worldwide and its diagnosis as well as early treatment is associat

Karachi, Pakistan
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CompletedPhase 3

Ketamine As an Adjunctive Therapy for Major Depression (2)

Pragmatic, randomised, controlled, parallel-group, superiority trial of ketamine vs. midazolam as an adjunctive therapy for depression.

Dublin, Ireland
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Recruiting

Vortioxetine for Cognitive Function in ALK-positive NSCLC Treated With Lorlatinib

This observational study evaluates whether vortioxetine - an antidepressant medication with cognitive-enhancing properties - can reduce the neurological and cognitive side effects associated with lorlatinib treatment in patients with non-sm

Bogotá, Colombia
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CompletedPhase 1

Sleep and Healthy Aging Research on Depression for Younger Women

Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects

Los Angeles, California, United States
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UnknownN/A

Comparing Different Patterns of rTMS in Major Depression

This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs.

Toronto, Ontario, Canada+1 more
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CompletedPhase 4

Dynamic Measures of Neurochemistry in Mood Disorders

The purpose of this study is to understand changes in brain chemical signals when people take antidepressants called sertraline (Zoloft®) and bupropion (Wellbutrin SR, Zyban ®). Spinal fluid is used to measure chemical levels of dopamine, s

Nashville, Tennessee, United States
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CompletedPhase 4

Brain GABA Levels and Treatment Response in Major Depressive Disorder

This study will evaluate changes in brain gamma-aminobutyric acid (GABA) levels due to treatment with escitalopram in people with major depressive disorder.

Boston, Massachusetts, United States
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CompletedEARLY_Phase 1

An Intervention Study to Increase Physical Activity and Maternal Well-being During Pregnancy

To refine, implement and evaluate a motivationally-tailored exercise intervention for increasing physical activity and mental health during pregnancy and the postpartum.

Montreal, Quebec, Canada
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CompletedN/A

Light Therapy for University Students

The effects of light therapy on well-being among university students was investigated. A three-week intervention study examined whether the use of light glasses improved sleep quality and concentration and reduced symptoms of depression and

Reykjavik, Iceland
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RecruitingN/A

HD-tDCS for Adolescent Bipolar Depression Targeting S1

This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy and underlying biological mechanisms of HD-tDCS targeting the primary somatosensory cortex in adolescents with bipolar depression. Participants will

Nanjing, Jiangsu, China
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CompletedN/A

Healthy Mood Internet Recruitment Study

This study is pilot testing a self-help automated Website (similar to a self-help book) designed to help individuals to learn methods to manage their mood. The methods are cognitive-behavioral skills found effective in the treatment of depr

San Francisco, California, United States
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Completed

Prevalence and Variables Associated With Depression in Subjects With Chronic Wounds Using PHQ-9 as a Screening Tool

The objective of the study is to complete a retrospective chart review of subjects who were treated at the Wound Care Clinic at Methodist Dallas Medical Center, presented for treatment between June 2018 and February 2019, and were administe

Dallas, Texas, United States
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WithdrawnPhase 4

Ketamine Frequency Treatment for Major Depressive Disorder

Depression is a wide spread illness. Depression contributes most significantly to national health care costs.

Duluth, Minnesota, United States
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WithdrawnPhase 2

e-PAT Neuromod Evaluation of Personalized rTMS for Resistant Depression

Although repetitive trans-cranial magnetic stimulation (rTMS) is an effective therapy for resistant depression, it still fail to remit up to 70% of these patients. We hypothesize that personalizing the procedure using functional MRI to bett

Multiple locations
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CompletedPhase 4

Trial of Levomilnacipran in Geriatric Depression

The purpose of this study is to examine the effects of levomilnacipran (FETZIMA) compared to placebo for the treatment of depression in older adults.

Los Angeles, California, United States
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CompletedPhase 1 / Phase 2

Zelquistinel in the Treatment of Adults With Major Depressive Disorder

The purpose of this study is to evaluate the efficacy and safety of AGN-241751 in participants with Major Depressive Disorder

Phoenix, Arizona, United States+4 more
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Unknown

QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease

The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder, cerebral pals

Split, Croatia+1 more
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