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UnknownN/A

Direct Information to At-risk Relatives

This study evaluates if uptake of genetic counselling in high-risk families is increased when patients at cancer genetics clinics are being offered healthcare-assisted disclosure to at-risk relatives compared to current standard care (with

Umeå, Sweden
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CompletedPhase 4

Pharmacology of Adjuvant Hormonotherapy in Breast Cancer

This is a biomedical study of interventional type, multicenter, inter-regional. Patients with hormono-depending breast cancer, for which an indication of adjuvant hormonotherapy treatment (according to the current treatments) was retained,

Agen, France+23 more
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CompletedPhase 3

Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED)

The purpose of this study is to determine the efficacy and tolerability of an investigational drug for the prevention of chemotherapy-induced nausea and vomiting associated with moderately emetogenic chemotherapy.

Multiple locations
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Active, not recruitingN/A

Study of Radiation Fractionation on Patient Outcomes After Breast REConstruction (FABREC) for Invasive Breast Carcinoma

This study is a randomized trial of hypofractionation (short-course) radiation therapy versus conventional radiation therapy in women who have undergone mastectomy and immediate breast reconstruction. The investigators will assess cosmetic

San Francisco, California, United States+14 more
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UnknownPhase 2

Tesetaxel Every 3 Weeks vs Weekly vs Capecitabine as 1st-line Therapy for Locally Advanced or Metastatic Breast Cancer

This study is being conducted to compare the efficacy and safety of tesetaxel administered once every 3 weeks in a 21-day cycle, tesetaxel administered once weekly for 3 consecutive weeks in a 28-day cycle, and capecitabine administered twi

Memphis, Tennessee, United States
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TerminatedPhase 1 / Phase 2

Navelbine, Taxol, Herceptin and Neupogen in Stage IV Breast Cancer: A Phase I - II Trial

The purposes of this are: * To determine the highest doses of Taxol and Navelbine that we can safely give to patients; * To determine what kind of side effects are caused by the combination of Taxol, Navelbine and G-CSF; * To determine whe

Seattle, Washington, United States
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CompletedN/A

A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women

This clinical trial tests whether a new dietary pattern that consists of foods that lower the blood insulin response can reduce breast cancer risk in high-risk women. In a large group of patients, this new dietary pattern was associated wit

Columbus, Ohio, United States
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CompletedPhase 1

A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833

The clinical study entitled "A Phase I Study of Infusional Chemotherapy with the P-glycoprotein Antagonist PSC 833" seeks to determine the maximum tolerated dose for a proposed P-glycoprotein antagonist, PSC 833. PSC 833 is a cyclosporine a

Bethesda, Maryland, United States
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WithdrawnEARLY_Phase 1

The Use of Metformin in Early Breast Cancer Patients Pre-Surgery

The study will test metformin in patients with early breast cancer. Blood and tissue will be collected before and after the use of metformin.

Rio de Janeiro, Rio de Janeiro, Brazil
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CompletedPhase 1

Multipeptide Vaccine for Advanced Breast Cancer

This is a study on how to activate the immune system with a vaccine. The vaccine is made up of two proteins found in breast cancer: telomerase and survivin.

Philadelphia, Pennsylvania, United States
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CompletedN/A

Feasibility Study of Breast MRI in Decubitus Position

Breast MRI is performed in prone position which causes a number of questions. Indeed, the correlation with mammography and echography and the identification of preoperative lesions can be complex as echography and surgery are carried in sup

Vandœuvre-lès-Nancy, France
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RecruitingN/A

Effect of Resisted Deep Breathing and Myofascial Release in Postmastectomy

This study aims to determine the combined effect of resisted deep breathing and Myofascial release on pain, respiratory efficiency, chest mobility and lymph edema in Postmastectomy.

Lahore, Punjab Province, Pakistan
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CompletedPhase 3

Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

This study is to compare the safety and effects of donepezil (Aricept) for patients reporting cognitive or memory issues after receiving chemotherapy for breast cancer. Patients will receive either donepezil or placebo for 24 weeks.

Anaheim, California, United States+277 more
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WithdrawnPhase 2

Combination Liposomal Irinotecan and Pembrolizumab For Triple-Negative Breast Cancer (TNBC) With Brain Metastases (BM)

The study is a phase II with safety lead in, single arm, study using Nal-IRI in combination with pembrolizumab. Nal-IRI will be given IV every 2 weeks starting at 50mg/m2.

Multiple locations
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CompletedPhase 1 / Phase 2

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

The purpose of this study was to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in participants with certain cancers. This study was conducted in 2 phases, Phase 1 and Phase 2.

La Jolla, California, United States+23 more
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CompletedPhase 1

SU5416 and Doxorubicin in Treating Patients With Stage IIIB or Stage IV Inflammatory Breast Cancer

RATIONALE: SU5416 may stop the growth of breast cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

Cleveland, Ohio, United States
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CompletedPhase 1 / Phase 2

Chemotherapy in Treating Patients With Breast Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I/II trial to study the effectiveness of annamycin liposomal in treating patients who have locally advanc

New York, New York, United States
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RecruitingEARLY_Phase 1

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

This study is to determine if low level vagus nerve stimulation will lead to improvement in heart function, heart rate variation, and in the levels of certain chemical markers of inflammation in study participants' blood.

Oklahoma City, Oklahoma, United States+1 more
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UnknownN/A

Efficacity of Deep Inspiration Breath Hold and Intensity-modulated Radiotherapy in Preventing PErfusion Defect for Left Sided Breast Cancer (EDIPE)

Breast irradiation is known to cause radiation-induced heart disease (RIHD) many years later after radiotherapy. Recent studies suggest that RIHD could be an earlier complication and that subclinical cardiac injury can be detected such as m

Strasbourg, France
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Available

Managed Access Programs for BYL719, Alpelisib

The purpose of this registration is to list Managed Access Programs (MAPs) related to BYL719, Alpelisib

Multiple locations
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