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TerminatedN/A

Home-based tDCS for Apathy in Alzheimer's Disease

The purpose of this study is to assess feasibility, acceptability, and safety of providing tDCS to Alzheimer's disease and related dementias (ADRD) patients with apathy and to assess the efficacy of tDCS for ADRD-related symptoms, with a pr

Houston, Texas, United States
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Terminated

The Role of Mid-Life Adiposity in Functional Brain Connectivity

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's d

Milwaukee, Wisconsin, United States
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CompletedPhase 1

An Study to Determine the Bioavailability of E2609 Tablets Compared to Capsules and the Effect of Food on Absorption

This study will be a single-center, open-label, randomized, 3-treatment crossover study of single oral doses of an API-capsule formulation of E2609 under fasted conditions and a tablet formulation administered under fed and fasted condition

Glendale, California, United States
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CompletedPhase 2

Short Term Effects of PRX-03140 in Patients With Mild Alzheimer's Disease Being Treated With Aricept

This is a study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PRX-03140 administered orally once daily for 14 days in subjects with mild Alzheimer's Disease who are using a stable, well-tolerated 10 mg dose

Paramount, California, United States+16 more
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Recruiting

NeuroCare Community Project: A Community Based Prospective Observational Study for Early Alzheimer's Detection in HK

Population aging is reshaping societal dynamics and presents significant global challenges. By 2050, it is projected that 1.6 billion people worldwide will be over the age of 65.

Hong Kong, China
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CompletedPhase 1

Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease (AD)

This study will evaluate the safety and tolerability and Aß-specific antibody response of CAD106 in patients with mild to moderate Alzheimer's Disease. Patients also had a 2 year follow-up to assess disease progression where no drug was adm

Malmö, Sweden+2 more
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Completed

Epileptic Activity in Patients With Alzheimer's Disease and Lewy Body Dementia

In the current study, the investigators will examine the extent of subclinical epileptic activity in patients with Alzheimer's disease and patients with Lewy body dementia as compared to healthy elderly controls. The participants will wear

Copenhagen, Copenhagen OE, Denmark+1 more
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RecruitingN/A

Investigating if a Stronger tDCS Intensity is More Effective for Improving Naming Ability in People Living With Alzheimer's Disease

There is currently little symptomatic therapy for Alzheimer's Disease (AD) and nothing effective for individuals with Frontotemporal dementia (FTD). However, neuromodulation with transcranial direct current stimulation (tDCS) has the potent

Toronto, Ontario, Canada
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Recruiting

InRAD Observational Study

The goal of this international observational study is to evaluate long-term disease outcomes and treatment safety in people with Alzheimer's disease (PwAD), by collecting real-world data from routine clinical practice across global clinical

Schwarzach, Austria+6 more
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CompletedPhase 3

A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment

The purpose of this follow-up study is to assess the long-term safety and tolerability of galantamine in individuals with mild cognitive impairment who participated in a previous study with galantamine

Multiple locations
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Active, not recruitingN/A

Clinical Safety and Efficacy of Fecal Microbiota Transplantation (FMT) in the Treatment of Alzheimer's Disease

To investigate the clinical safety and efficacy of FMT in AD patients, as well as the changes in the gut microbiota of AD patients before and after FMT.

Shanghai, China
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RecruitingPhase 2

Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)

The goal of this placebo-controlled double-blind Phase 2 clinical trial is to test in people with early Alzheimer's Disease. The main questions it aims to answer are: * Does treatment with fasudil, a ROCK-inhibitor, lead to significant imp

Tromsø, Nordland, Norway+5 more
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CompletedPhase 1 / Phase 2

A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET)

The purpose of this study is to evaluate the ability to identify individuals with dopaminergic degeneration in group of patients with a clinical diagnosis of either dementia with Lewy bodies (DLB) or idiopathic Parkinson's disease and to di

Sun City, Arizona, United States+1 more
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CompletedPhase 4

Efficacy, Safety and Tolerability of Rivastigmine Patch in Patients With Mild to Moderate Alzheimer's Disease Switched From Cholinesterase Inhibitors

This is a multicenter study to evaluate the efficacy, safety and tolerability of Rivastigmine patch in patients with mild to moderate Alzheimer's disease switched from Cholinesterase Inhibitors.

Nagoya, Aichi-ken, Japan+10 more
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Completed

Multi-parameter Diagnostic Blood Test for the Diagnosis of Alzheimer's Disease

The purpose of this study is to validate a diagnostic test that combines different blood markers to identify and correctly classify patients with Alzheimer's disease (AD) compared to individuals with behavioural variant frontotemporal demen

Bruges, Belgium+15 more
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CompletedN/A

Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture

To determine if adjunctive acupuncture acts as an AD treatment rather than a placebo.

Shanghai, China
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CompletedN/A

LatAm-FINGERS Initiative for Cognitive Change

Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors. At the moment, there are no medications that halt the clinical expression

Ciudad Autonoma de Buenos Aire, Argentina+12 more
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RecruitingPhase 2

Transcranial Pulse Stimulation for Alzheimer's Disease

TPS is a non-invasive therapeutic modality that uses focused, low-energy pulse stimulation to stimulate tissue regeneration and reduce inflammation. In the context of neurological disorders, it is hypothesized that TPS can modulate neuronal

Hong Kong, Hong Kong
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CompletedPhase 2

Caring Light Project for Family Caregivers

Caring Light is designed to help caregivers of someone with Alzheimer's Disease and related dementia to cope with the difficulties related to caregiving, reduce stress, and improve quality of life.

Mountain View, California, United States
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CompletedPhase 3

Estrogen Hormone Protocol

Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries.

Birmingham, Alabama, United States+24 more
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