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By invitation

Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

Participants enrolled at the Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine will be invited to take part in this study. The purpose of this study is to identify and measure the amount of a protein called amyloi

Winston-Salem, North Carolina, United States
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CompletedPhase 1

Phase I, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of an M1 Agonist to Treat Cognitive Impairment

The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics in young and elderly healthy volunteers of HTL9936, a selective M1 receptor agonist intended for the treatment of cognitive disorders.

Harrow, Middlesex, United Kingdom
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Completed

Autobiographical Specificity

Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However,

Nantes, France
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CompletedPhase 2

A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)

The purpose of this study is to evaluate the safety, tolerability and efficacy of LY3002813 in early symptomatic Alzheimer's disease.

Phoenix, Arizona, United States+60 more
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TerminatedPhase 3

Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects

This study is being conducted to evaluate the long-term safety and efficacy of ALZ-801 in Early Alzheimer's disease (AD) subjects with the APOE4/4 genotype. This is an open-label trial of treatment with ALZ-801.

Phoenix, Arizona, United States+40 more
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CompletedPhase 2

Meditation or Education for Alzheimer Caregivers

The goal is to determine how 6-week stress reduction techniques may decrease stress in primary caregivers of people with Alzheimer's disease. The 3 intervention programs are meditation, education, and respite care.

Portland, Oregon, United States
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CompletedN/A

A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1

The purpose of this research study is to investigate the relationship between reminder messages sent via text and compliance with a daily morning light intervention designed to advance the circadian clock. Twenty healthy adults will be recr

Menands, New York, United States
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RecruitingPhase 2

Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and ea

Columbia, South Carolina, United States
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Recruiting

Ruijin Neurobank of Alzheimer's Disease and Dementia

The goal of this observational study is to learn about neuroimage and biomarkers in the Alzheimer's continuum. The main questions it aims to answer are: * How is the neurovascular coupling during AD pathogenesis?

Shanghai, Shanghai Municipality, China
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CompletedPhase 1

Study of Nasal Insulin to Fight Forgetfulness - Short-Acting Insulin Aspart

This pilot clinical trial will examine the effects of intranasal insulin aspart on cognition, daily function, blood and cerebral spinal fluid markers of Alzheimer's disease, and amyloid deposition in the brain. Participants will be randomly

Winston-Salem, North Carolina, United States
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WithdrawnN/A

Brain Sleep Deprivation MRI Effects (BEDTIME)

The primary purpose of this study is to explore the underlying mechanisms that link sleep to Alzheimer's disease (AD), with special focus on the clearance of metabolites in the extracellular space of the brain during sleep. Subjects will we

New York, New York, United States
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Active, not recruitingPhase 1

Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease

The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the advantages and caveats of their use in clini

Berkeley, California, United States+8 more
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UnknownN/A

Intervention Programs for Decreasing Caregiver Burden in Caregivers of Patients With Dementia

The purpose of this study is to investigate if behavioral intervention for dementia caregivers will decrease caregiver burden in caregivers of patients with dementia. This multicenter, randomized trial will be conducted with 80 dementia car

Multiple locations
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CompletedPhase 1

Augmenting Flortaucipir Dosimetry Estimates

This study will obtain data from urine in subjects administered flortaucipir in an Avid-sponsored study to augment the calculation of radiation dosimetry estimates.

New Haven, Connecticut, United States
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CompletedN/A

Reducing Agitation in People With Dementia: the Customized Activity Trial

Over 5 million Americans have Alzheimer's disease or a related dementia, a progressive and irreversible neurodegenerative condition, affecting also close to 15 million family caregivers (CG). A hallmark of the disease and one of the most si

Baltimore, Maryland, United States
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Completed

Blood-brain Barrier Permeability in Alzheimer's Disease

The main aim of the present study is to improve our understanding of the role of blood-brain barrier function in dementia of the Alzheimer's type. The investigators hypothesize that microvascular dysfunction - more specifically "cerebral pe

Leiden, Netherlands+1 more
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UnknownPhase 2

The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy

Background and objects Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and tau protein accumulation.

Taoyuan, Guishan, Taiwan
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RecruitingN/A

Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms

Participants will be asked to participate in this research study of a device that creates transcranial direct current stimulation (tDCS). The researchers hope to learn if 30 minute sessions of transcranial direct current stimulation (tDCS)

San Antonio, Texas, United States
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Terminated

Follow-up Study to Evaluate Long-term Safety and Tolerability of Immunization With AD03 Applied During AFF005A

This is a phase Ib follow-up study to evaluate long-term safety and tolerability of immunization with AFFITOPE AD03 applied during AFFiRiS 005A.

Vienna, Austria+1 more
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CompletedN/A

Playful Multimodal Intervention, Monitoring and Decision Support for Activation of People With Alzheimer's Dementia

The worldwide prevalence of dementia is increasing. Pharmaceutical therapies, at the best, slow the degenerative process, observable in Alzheimer's disease (AD).

Graz, Styria, Austria
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